I have a Smith and Wesson M&P 45 ACP. Mine lacks the manual safety. I overcome this by following the fundamental firearms safety rules (finger off the trigger unless I'm about to shoot, only point at that which you intend to destroy, etc...).
I also carry the M&P 45 without the manual safety. The post i was responding to was opining for a pistol with a manual safety, so I recommend the M&P with the optional safety. The point being that the M&P offers the optional safety and the Glock does not.