Taking the hard drive out and scanning it ‘hot swapped’ into an external box from another machine might work.
As long as the drive itself is not the active drive, the virus should not be a problem and should be able ot be removed.
Operative word being ‘should’.
Also, you need to know what the file name and location is that you are looking to delete.
What to you mean by ‘active drive?’
I concur with Darksheare.
I’ve done quite a lot of malware and virus repair, and sometimes that is the ONLY way to clean a drive short of re-formatting it and starting over.