Not good.
I found that out the hard way (no pun) a few years back when an accupuncturist suggest some chinese herb thing for pain.
I went to the doc dumbfounded at why my gut froze up as I was then eating a mostly high rougage diet.
First thing he asked what supplements are you taking when I told him he got that no wonder look on his face and told me knock of the chinese herb (can remember what the hell it was) as too much of a good thing can do the oppisite of what is intended.
Neverdem has some good pings to allot of bio/med threads and how each of our bodies interact with endocrine/diet/medical issues ect.
Well researched IMO.
So yeah metab/endocrine is a huge factor, like the thyroid hormone it runs just about everything in the body, I liken it to the idle system of a car.
So much in health and our individual body functions is so intertwined.
I like science that works on unraveling how it all relates as opposed to pharma cures that can kill.
And with your BP/metab issues you have to be really careful as you know about what you put in your body no matter how organic it is, it all tweeks the system.
Lowered my bp by getting a pet.