Are there any revolvers where the cylinder swings out on the right side? It would make it easier for a lefty to unload/reload.
I simply bump the latch with my trigger finger, punch the cylinder out with my right thumb, grasping the frame with my fingers underneath the trigger guard/bottom metal , muzzle upward, slap the ejector rod with the knife edge of my left hand, continue down to my speed loader carrier (same side as my holster) bring it up while flipping the muzzle down, insert, twist, close, re-grasp and re-engage.... I feel very comfortable with this method.
God Bless & MOLON LABE.