Here’s one ( I’ve been lobbying Jim for years to add this capability to FR ) that really cuts down on the flamewars:
http://userscripts.org/scripts/show/4107
killfile
Provides a killfile for certain blogs. Covers livejournal, haloscan comments, most typepad blogs, most blogspot blogs, scienceblogs.com, and more as I add them. Trolls can be killfiled with a single click.
I used a killfile back on usenet, alt.politics.whitewater, and all. Eventually I had every poster in it. Very boring.