The spelling police.
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Please excuse my earlier sarcasm. As for .22...if the intention is personal defense then a low power, fragmenting LR is the way to go but, as with any small caliber, the target is the pelvic bone to the rib cage (the soft tissue protected organs) or else your target may make you eat your gun. In the seventies I knew a street guy in Harlem who took seven hits from a .22 and didn't go down. His street name was Champ.