I had a doc recommend Avandia vs. metformin. Glad I ignored his advice.
I take Avandia and metformin but have had better results from Avandamet, a combination of both in one pill. There have been some quality control problems though and it's been on and off the market. It's back on now and I have some on order, hope my mail-order pharmacy is carrying it again.
Lizard Spit should be all diabetics drug of choice:
http://www.centerwatch.com/patient/drugs/dru879.html
Byetta (exenatide), derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide which enhances insulin secretion in response to elevated plasma glucose levels. By mimicking the function of GLP-1, the drug helps more strongly activate this pathway to improve glycemic control.
I've been on Metformin for about 2 years now, and have had no ill effects. I also consult 4 times a year with my endocrinologist, and am taking all the other necessary precautions (diet, exercise, weight loss), so I guess that makes me a trial lawyer's pariah...