There have been very recent experiments in heat resistant bacteria in which every possible point mutation in the relevant genes was observed. Therefore there are at least some instances in which the source of variation -- random or not -- is irrelevant.
Selection is biased. bad throws of the dice are discarded
Selection applies equally to random (e.g. Evolution) and biased (e.g. Intelligent Design) sequencing, so Selection is **NOT** a factor.
You seem a bit tongue-tied, though...as if you don't want to be pinned down to answering my "random or biased" sequencing question of you.
Your hesitation to give a firm answer should clue you in that deep down you already know that your argument has lost.