There have been so many 'resets' in comic book continuity that I gave up entirely on new comics and now just reread silver & bronze age comics in my collection, or reprints. To answer the question, based on continuity still valid through the 1970s and into the 1980s, Lois is aware of Lana and Lori.
Strange how those "Double L's" keep popping up in Superman's life. Hmmm, and all that recent talk about the new Batwoman being a "Lipstick Lesbian." :-)