The thing to remember is to think about where you will be hunting and then select the bullet weight from there. Are you going to be in woods were a stick/twig/small branch may be encountered during shooting. If so, heavier bullets are better.
I used to hunt in woods in MI and so I would use 180 grain bullets. I use Winchester SilverTips (the originals). I have a box of original Black Talons in 180 grain that I have not shot yet. I was contemplating reloding using the Combined Technologies FailSafe bullets but I am looking at the Barnes TSX bullets.
The hunting would be in Pa.
I'd love to hunt out West someday.