"we are not the playthings of supernatural intervention, that we can make our own way in the universe"
Are you suggesting that assertions about purpose are the product of scientific evidence? Having purpose in the universe sans "supernatural intervention" is a theological position. One that denies that the God that most Americans are familiar with exists.
To say that science doesn't reveal a purpose is not the same thing as saying there is no purpose. To say that IF there is no purpose to the universe, we still have a purpose, is not a scientific statement but Weinberg's opinion, and I stronly agree with it.
One that denies that the God that most Americans are familiar with exists.
Insofar as "the God most [insert culture here] are familiar with" behaves in a manner contradicted by the discoveries of science, he, she or it must be denied. Again, science is under no requirement not to contradict the specific beliefs of specific religions.