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Statins: Still Overhyped After All These Years
Coach is Right ^ | 6/17/15 | Michael D. Shaw

Posted on 06/17/2015 9:00:12 AM PDT by Oldpuppymax

In a rather self-serving review article entitled “A historical perspective on the discovery of statins,” Japanese biochemist Akira Endo hits all the conventional and PC notes in his 10-page (including references) trip down memory lane. From the get-go, in the abstract itself he tells us that…

“Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs–the statins–that lower cholesterol levels in blood and reduce the frequency of heart attacks.”

We would expect nothing less from Endo, considered the father of statin drugs, had this article been published in the 1990s. But, appearing as it did in May, 2010, in the Proceedings of the Japan Academy, his astonishingly uninformed portrayal of coronary disease etiology; and the modest benefits of statin therapy–let alone their devastating side effects–give a whole new meaning to the term “Ivory Tower.”

Endo was inspired by the work of Nobel prize winning bacteriologist Alexander Fleming, who discovered the antibiotic substance benzylpenicillin (Penicillin G) from the fungus Penicillium notatum. As such, on his mission to save the world from cholesterol, Endo began searching in 1968 for fungi that might produce an inhibitor for Hydroxymethylglutaryl-coenzyme A reductase, a key enzyme in the biosynthesis of cholesterol. Inasmuch as he acknowledges that cholesterol is “essential for the functioning of all human organs,” one wonders why he thought grossly interfering with its synthesis would be a good idea.

Indeed, Endo’s describing his search for a HMG-CoA Reductase inhibitor in the same context with one of the first–and still widely used–antibiotics is perilously close to medical blasphemy. Nonetheless, Endo’s work eventually led to...

(Excerpt) Read more at coachisright.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: cholesterol; heartattacks; ironcurtain; jama; ontheadriatic; onthebaltic; statin; statins; trieste

1 posted on 06/17/2015 9:00:13 AM PDT by Oldpuppymax
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To: Oldpuppymax

Wow! Who to believe...


2 posted on 06/17/2015 9:19:06 AM PDT by SgtHooper (Anyone who remembers the 60's, wasn't there!)
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To: Oldpuppymax

3 posted on 06/17/2015 9:25:12 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: Oldpuppymax

> but it is nevertheless the cause of coronary heart disease

Correlation isn’t causation. Just because there is cholesterol obstructions in someone’s arteries doesn’t mean cholesterol caused them. The question should be “what is causing the cholesterol to clot?”


4 posted on 06/17/2015 9:26:32 AM PDT by glorgau
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To: Oldpuppymax
A quick consultation of several medical sites list numerous potential side effects to statins, including some that I experienced while taking my prescribed Crestor; headaches and dizziness. They also describe early onset of Alzheimer's as a potential effect.

Great. So I lower my cholesterol and avoid heart attack but my brain goes out early! Talk about Pyrrhic victories!

I stopped taking the Crestor (much to my doctor's annoyance) and decided to reduce weight and pick up the pace on my bicycle riding.

All drugs are a balances of benefits versus dangers.

5 posted on 06/17/2015 9:31:45 AM PDT by Chainmail (A simple rule of life: if you can be blamed, you're responsible.)
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To: Oldpuppymax
Pharms and their hand-selected favorable outcome studies submitted for publication and regurgitation. Frustrating. Nothing but propaganda. "People will believe a big lie sooner than a little one; and if you repeat it frequently enough people will sooner or later believe it".
6 posted on 06/17/2015 9:36:29 AM PDT by TennesseeGirl (Those who don't know history are doomed to repeat it. - Edmund Burke 1790)
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To: glorgau

I thought sugar made the cholesterol clot. Those on high protien, high fat, low carb diets lose weight and cholesterol.


7 posted on 06/17/2015 9:40:11 AM PDT by goodwithagun (My gun has killed fewer people than Ted Kennedy's car.)
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To: goodwithagun

I lost weight on a high protien, high fat, diet. (Cheezeburgers, mostly - no bread) however, cholesterol went off the charts.


8 posted on 06/17/2015 9:55:26 AM PDT by loungitude (The truth hurts.)
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To: Oldpuppymax
I always wonder if my doctor is getting a kickback from Crestor.
9 posted on 06/17/2015 9:56:21 AM PDT by McGruff (It's gonna get ugly round here.)
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To: Oldpuppymax

I’ve had good results with Lipitor with no side effects.


10 posted on 06/17/2015 10:07:25 AM PDT by beethovenfan (Islam is a cancer on civilization.)
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To: beethovenfan

Lipitor, Crestor both gave me muscle aches.
I had to stop taking both.
I switched to Simvistatin, but eventually stopped taking that too.


11 posted on 06/17/2015 10:49:30 AM PDT by woodbutcher1963
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To: Oldpuppymax

Want to lower your bad cholesterol and raise your good cholesterol without drugs? Do the following:

1) Eat about an ounce of almonds every day.

2) Have high dose Niacin (either buffered to avoid the flushing effect and/or with a large meal) - about 500-800 mg.

3) Have a glass of dry (or at worst, semi-sweet) RED wine a day.

4) Exercise for about 20-30 minutes, 5 times a week.

That is all you need. Pay no attention to Big Pharma and Big Medicine - they WANT you hooked on constant tests, constant doctors visits and a daily drug habit. My grandfather was a medical doctor for about 54 years, and his advice for staying healthy and living a long life was to “stay away from doctors and stay away from hospitals.” Obviously, he said, if your bone is sticking out of your arm or legs, or any similar actual emergency, then go to the hospital ASAP. Otherwise, depend on the body that G-d gave us all; with modern sanitation and looking both ways when you cross the street, most of us should live to between 80 and 90.


12 posted on 06/17/2015 10:58:26 AM PDT by Ancesthntr ("The right to buy weapons is the right to be free." A. E. van Vogt)
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To: Oldpuppymax
More info:

http://knowledgeofhealth.com/something-huge-is-going-on-in-cholesterol-world/

Statins have a lot of bad side effects, and they have not been proven to be effective in lowering cholesterol.

But they are the drug de jour.

13 posted on 06/17/2015 11:09:56 AM PDT by exit82 ("The Taliban is on the inside of the building" E. Nordstrom 10-10-12)
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To: Ancesthntr

Statins screw me up. My doctor has me on 2000mg niacin and 2400mg red rice yeast. I also drink red wine, exercise, and keep stress down.


14 posted on 06/17/2015 11:46:51 AM PDT by bravo whiskey (we shouldn't fear the government. the government should fear us.)
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To: woodbutcher1963

Muscle pain can be a symptom of a serious problem. A certain percentage of people cannot take statins for this reason. I’ve been fortunate.


15 posted on 06/17/2015 12:05:57 PM PDT by beethovenfan (Islam is a cancer on civilization.)
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To: bravo whiskey

You do, of course know that the natural source of all the new statin drugs was... red yeast rice!


16 posted on 06/17/2015 12:18:16 PM PDT by djf (OK. Well, now, lemme try to make this clear: If you LIKE your lasagna, you can KEEP your lasagna!)
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To: Chainmail
Here is something you might want to check out:

The Triglyceride/HDL Cholesterol Ratio

There is a pretty good summary of cholesterol and triglyceride ratios. You can also search engine Triglyceride and HDL ratios for more reading.

The writer waited (I think grudgingly) till the end of the piece to state what many have figured out already.

Although low-fat diets may help lowering LDL-C, low carbohydrate diets are more effective in improving the TG/HDL-C ratio.

The only thing I would add to this is the inclusion of a NIASPAN regimen to increase HDL levels.

I figured this out the hard way after following strictly medical advice for a hypercoagulable blood condition. I was placed on a very low fat and high carbohydrate diet with disastrous results. I switched to a very low carb (VLC) diet over ten years ago and have been clot free since.

YMMV
17 posted on 06/17/2015 1:15:24 PM PDT by PA Engineer (Liberate America from the Occupation Media. #2ndAmendmentMatters)
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To: PA Engineer

Thank You!


18 posted on 06/18/2015 3:22:26 AM PDT by Chainmail (A simple rule of life: if you can be blamed, you're responsible.)
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To: beethovenfan

What is interesting is that my older brother took Crestor for 5 years and never had any side effects. He stopped taking them because he eventually demanded that his doctor give him a stress test(I think) to measure if he had any clogged arteries. The test showed nothing, so he stopped taking them. His wife was also a cardiac RN that worked at Georgetown University medical center. He works out regularly and drinks red wine daily.


19 posted on 06/18/2015 6:09:49 AM PDT by woodbutcher1963
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