I run and swear by Mailwasher mentioned above and
Ad-aware. Dowload Ad-aware 5.83 PLUS the ref sig file 042-24.9.2002 and run it. "Ad-aware is a free multi spyware removal utility that scans your memory, registry and hard drives for known spyware and scumware components and lets you remove them safely. It is updated frequently."
I just had trouble with Xupiter and didn't have Ad-aware's ref sig. As soon as I downloaded that, Ad-aware found 17 instances of Xupiter AND CLEANED IT UP! Even with an updated anti-virus, a firewall, Mailwasher, Cookie Pal and Ad-aware, I still got Xupiter and have no idea how.
I am a professional geek, and after cleaning my home system myself, I loaded Ad-aware and ran a sweep. There were five more instances of sneakware still in my system that Ad-aware safely removed. It is free, it works great, even better than a geek.