[Dr. Franklin]

Isadora said that a man who identifies as a woman is still “born male” and “retains their birth DNA.”

No a man who is born a man with an "X" chromosome retains HIS birth DNA, even if he chops off a body part.

[hanamizu]

No a man who is born a man with an “X” chromosome retains HIS birth DNA

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All men get an X chromosome, from their mother. He is male because he received the Y chromosome from his dad. Chopping off or otherwise modifying body parts doesn’t change his DNA. If it still exists hundreds of years from now, his skeleton will still be a male skeleton.