I’ve researched various blood clotting factors as a result of caring for a family friend who moved into our home as a result of a severe stroke.
When we are in our mother’s womb, our lungs do not function. There is no respiration. Rather than blood being pumped from the right atrium to the right ventricle and on through the pulmonary artery to the lungs, and finally back to the left atrium, there is a hole through the septum between the right and left atrium.
This hole, called a patent foramen ovale or (PFO), allows the blood to bypass the lungs and go directly to the left atrium, and then to the left ventricle where it is pumped through the brain and the rest of the body.
This hole or PFO normally closes after birth, forcing the blood to flow through the lungs where it releases CO2 and becomes oxygenated.
However, in about 30% of the population this hole never closes. If it is open, blood clots that would normally get screened in the lungs and become a pulmonary embolism get pumped directly through the hole and end up in the brain causing strokes. Life expectancy depends upon the size of the PFO. Most people who have them are unaware of it. It can be surgically corrected.
There are over a dozen blood clotting factors. The one referenced in this article is Factor 4.
Platelet factor 4 (PF4), or CXCL4, is a small cytokine protein released by activated platelets during blood clotting, crucial for promoting coagulation and immune responses. It binds heparin, plays a role in heparin-induced thrombocytopenia (HIT), and has been identified as a potential factor in brain rejuvenation.
Key details regarding PF4:
Function: Released from platelet
-granules, it accelerates blood clotting and aids in inflammation.
Clinical Significance: PF4 binds to heparin, and antibodies against this complex can cause Heparin-Induced Thrombocytopenia (HIT). It is also implicated in vaccine-induced immune thrombotic thrombocytopenia (VITT).
Other Roles: It has anti-angiogenic properties (inhibits new blood vessel growth).
Research: Recent studies indicate PF4 may have rejuvenating effects on the brain.
In the specific case I spent weeks researching to help my friend, she had Factor V Leiden. Factor V Leiden is a common inherited genetic mutation that causes hypercoagulability, meaning the blood clots too easily.
She also had Von Willebrand factor (VWF), a critical blood glycoprotein that acts as “glue” to enable platelets to adhere to injured blood vessel walls, initiating blood clotting.
Thus the stroke was unique in that there were both clots and hemmorages. This made it very difficult to treat.
Her clotting factors were destabilized by high estrogen levels caused by a lower abdominal tumor.
“Platelet factor 4 (PF4), or CXCL4, is a small cytokine protein released by activated platelets during blood clotting, crucial for promoting coagulation and immune responses.”
That sounded familiar. A search brought up the following. Of course it is sold as a positive (enhancing the immune response), but I imagine it also increases the risk of a blot clot in “rare” cases.
AI Overview
mRNA COVID-19 vaccines (e.g., Pfizer-BioNTech, Moderna) induce an immune response by prompting cells to produce spike proteins
. This process, along with the lipid nanoparticles, increases cytokines (e.g., CXCL10, IFN-gamma) signaling immune activity. Cytokine levels, indicating humoral immune response, may remain altered for up to a year.
Key Details on mRNA Vaccines and Cytokines:
Cytokine Profile Changes: Vaccination results in an increased level of circulating cytokines, representing a persistent immune response.
Vaccine Mechanism: The mRNA-lipid nanoparticle structure is highly inflammatory, stimulating this cytokine production.
Specific Cytokines: Key cytokines involved include CXCL10 and IFN-gamma, which are involved in immune cell signaling.
Duration: Studies indicate that these altered cytokine profiles can persist for at least one year in some individuals, particularly younger adults.
Adjuvant Potential: Research is ongoing into using specific cytokines, such as interleukin-12 (IL-12), as adjuvants to further enhance the effectiveness of mRNA vaccine
If Factor PF4 blocks heparin, it blocks blood thinning. This directly allows increased clotting.
Heparin is often given during surgery to stop blood clots from forming or used after stroke to dissolve clots.
Heparin is primarily used after specific types of ischemic stroke—particularly cardioembolic—to prevent further clots, but its use is controversial due to high bleeding risk. It is generally not used for acute ischemic stroke without clear indication (like atrial fibrillation) or hemorrhagic stroke, as it can cause fatal brain hemorrhage.
“When we are in our mother’s womb, our lungs do not function.”
Babies’ lungs exercise via simulated breathing movements.
“There is no respiration”
There absolutely is respiration.
“However, in about 30% of the population this hole never closes. If it is open, blood clots that would normally get screened in the lungs and become a pulmonary embolism get pumped directly through the hole and end up in the brain causing strokes. “
You left out the word ‘rarely’.