Posted on 01/01/2026 5:23:24 PM PST by ConservativeMind
For over a century, Alzheimer's disease (AD) has been considered irreversible.
Now, research has challenged this long-held dogma in the field.
Through studying diverse preclinical mouse models and human AD brains, the team showed that the brain's failure to maintain normal levels of a central cellular energy molecule, NAD+, is a major driver of AD, and that maintaining proper NAD+ balance can prevent and even reverse the disease.
NAD+ levels decline naturally across the body, including the brain, as people age. Without proper NAD+ balance, cells eventually become unable to execute critical processes required for proper functioning and survival.
The team showed that the decline in NAD+ is even more severe in the brains of people with AD, and in mouse models.
The research team tested whether preventing the loss of brain NAD+ balance before disease onset, or restoring brain NAD+ balance after significant disease progression, could prevent or reverse AD, respectively.
The study was based on their previous work, showing that restoring the brain's NAD+ balance achieved pathological and functional recovery after severe, long-lasting traumatic brain injury. They restored NAD+ balance by administering a pharmacological agent (P7C3-A20).
Remarkably, not only did preserving NAD+ balance protect mice from developing AD, but delayed treatment in mice with advanced disease also enabled the brain to fix the major pathological events caused by the genetic mutations. Moreover, both lines of mice fully recovered cognitive function.
"Restoring the brain's energy balance achieved pathological and functional recovery in both lines of mice with advanced Alzheimer's. Seeing this effect in two very different animal models, strengthens the idea that restoring the brain's NAD+ balance might help patients recover from Alzheimer's."
Dr. Pieper emphasized that currently available over-the-counter NAD+ precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer.
(Excerpt) Read more at medicalxpress.com ...
“One I take is a powder form of nicotinamide riboside that lets me use a small 1/8 teaspoon to get under 50 mg of nicotinamide riboside. That is a fraction of normal doses in capsules.”
If you don’t mind, what’s the brand name and where do you get it?
Also have you been taking it for a while? If so have you noticed any changes to your body, how you feel?
R3ad somethi g the other day that they reversed it in mice with some substance- cant remember whzt now. Hope they are getting close to a cure or at least taming it severely.
Who mentioned diterpenes?
One person mentioned Gingko Biloba, but it wasn’t in any context around NAD+.
This is what I take, at 1/20th the suggested dose:
Renue By Science Nicotinamide Riboside | 1000mg Nicotinamide Powder - High Strength NR NAD Powder Sublingual Citrus Burst Flavor
https://www.amazon.com/dp/B0CVX411WW
There is no “cure” but prevention.
That stated they did already prove how to stop its progression; why does everyone emotionally support the corporate gaslighting that the only solution is a “perpetual” treatment, a pill that would net big pharma Covid sized profits?
Look to past research. “Micro bubbles.” They so-called ‘mystery’ was solved long ago, but they want a perpetual treatment. A daily pill. Profits (greed).
They can go straight to hell.
Could be dangerous to post such crap - man will start loading up their systems, “just in case” and suffer side effects that are yet unknown.
BKMK
Thanks for posting the article on Alzheimer disease reversal in animals. I always appreciate knowing the latest information on memory loss, dementia and Alzheimer.
Thanks. Have you noticed any impacts from it?
The amazing thing is that for the study I posted above, coupled with the three referenced in the other study I posted the same day on CaAKG helping Alzheimer's, they can be trialed without appreciable risk or cost. Some mineral waters have more lithium than I'm taking and I already had green tea and a multivitamin with standard Vitamin B3/nicotinamide, so it would just take shifting a multivitamin with nicotinamide to the same occasion, rather than wait. I have had nicotinamide riboside here for a number of years and have gone on and off of it, but hadn't been able to microdose it, for use as the most recent couple of studies have encouraged (a study came out early this year around high dose nicotinamide riboside encouraging the growth of triple-negative breast cancer—I posted it, then).
I have also implemented other changed, including doing Fasting Mimicking Diets multiple times, this past year. I have posted about this, too.
I tweak things when I find something out that I can implement for myself or my wife. This may mean I can't clearly identify improvements to a single change. That said, when I note an issue, I back off more recent changes to see if they resolve. Thankfully, that is a rare occurrence.
The other dementia/Alzheimer's studies I referenced are in this:
Naturally occurring molecule shown to restore memory function in Alzheimer's models
I stand corrected on that measure. I use 1/8th for a different supplement. I actually use 1/64 of a teaspoon, for this powder.
I lost my mother, who was an operating room nursing supervisor to it 20 years ago this month.
Sorry to hear that.
If I was you, I’d be quite angry at the medical industrial complex, particularly the Alzheimer’s Gaslighting & Fundraising Apparatus (AGFA).
Just as I am today at my having to diagnose my father to abject intransigence and outright fraud designed only to extract $$ from his plan and delivery little-to-no care to facilitate his recovery.
MDs are absolutely clueless in my experience (it gives me no pleasure to be right about that fact).
And I’ve stated my piece on medical research...
They don’t pass the blood-brain barrier. Good luck $$$$
We should not censor because some people might be stupid.
Most of these supplements have no real effect, but their use, for a few days is harmless. If you or somebody you know has an issue, there is little cost to trying a supplement for a few days, and seeing if you see any difference.
Most of these medical issues, IMO, are originating in the gut, where some bacteria is producing something which either triggers inflammation, or has some neurologicaal effect as an adaptation to try and exploit the enteric immune system, but it bleeds out into the blood and affects things systemically.
To that end, different vitamins and minerals can have an effect, just by altering what microbes are getting fed or not in the gut, and by altering gastric transit times.
All of that is way beyond research however. But people do have the very best, fully customized laboratory right in their living room - their own body. If you are definitely on the path to ending up with full blown dementia, try a supplement here and there, and see if you can feel a difference. Magnesium may be one of the most powerful, just because it can enhance gastric motility. B vitamins can get deficient, and I think the trace mineral supplement from Vitamin Shoppe, which has a good shot of lithium, can be helpful in cognitive issues as well.
Other stuff, SAMe, Phosphotidyl serine, fish oil, NAC NMN, NR, meh, there is no harm in trying it and seeing. Don’t triple dose, most of these things will probably have 80% of theeir effect at 50% of the dose.
IMO, the best possible thing anyone with these issues could do though, and the thing which I saw have the most dramatic effect in a relative with cognitive issues, is Traditional Chinese Medicine. I watched somebody completely out of it, become completely normal, to the point they had no idea why they were repeating the things they kept saying when screwed up, and it was done just off acupuncture alone.
The only issue with that is there are people doing it who are not good, and there are complete masters who will change your life, but you often just need to go to place after place until you find a master. Oddly enough the real masters are often the guys doing in in some weird hole in the wall, where you walk into a chinese hair salon, and the stylist points to you some back closet, where the guy is sitting at a desk that is falling apart. But that dude will be like an above-Einstein-tier genius who will take one look at you and even know stuff which happened to you in childhood, and see how it still manifests in how you think and hold yourself today. They can he really weird that way. But often even just an american-trained one with only half that master’s ability can help a lot, and a lot more than any supplements.
Another medical “breakthrough” that we’ll never hear about again.
That’s true of NAD itself. These supplements are NAD precursors...
“While direct NAD+ supplementation is not effective due to poor absorption, precursors such as NR and NMN are more bioavailable and have been shown to increase NAD+ levels in the blood.”
Ok, I will put it this way, as the science especially for humans is incomplete. Some get past the blood brain barrier/CNS and some don’t. “Are these NAD+ precursors effective?”
If “effective” means raising NAD+ levels, then several precursors (NR, NMN, nicotinamide/niacin) are effective, at least in blood and, for NR and nicotinamide, with evidence of CNS penetration and increased brain NAD+ in humans or animals.
If “effective” means proven improvement in human cognition, prevention of neurodegeneration, or clear functional brain outcomes, the data are preliminary, often small, and not yet definitive.
Nicotinamide riboside (NR)
Multiple human trials show NR (typically 1,000–3,000 mg/day) raises blood NAD+ 2–3 fold and is well tolerated, and in Parkinson’s disease (NADPARK/NR‑SAFE) it also raised cerebral NAD+ and modestly improved clinical motor scores.
In older adults with mild cognitive impairment, NR increased NAD+ but did not significantly improve overall cognition over 10–12 weeks, though some exploratory measures (e.g., executive function, fatigue, sleep quality) showed within‑group improvements.
Nicotinamide mononucleotide (NMN)
In animal models, systemic NMN after cardiac arrest increased brain NAD+ and ATP, upregulated SIRT3, and improved neurological scores and survival, indicating neuroprotection when given acutely.
Human data on brain‑specific outcomes are sparse; ongoing and early trials mainly assess systemic metabolic or aging markers, so “effectiveness” for human brain health remains speculative.
Niacin / nicotinamide (NAM)
Preclinical work shows NAM can cross into the CNS and protect neurons in models of Huntington’s disease, glaucoma, and oxidative stress, often by boosting NAD+ and reducing apoptotic signaling.
A large, definitive human neuroprotection trial is still lacking; glaucoma trials with high‑dose NAM are underway, but results are not yet conclusive for broad brain indications.
Practical bottom line
There is solid evidence that NR, NAM, and NMN can raise NAD+ and show neuroprotective effects in animals, and NR/NAM demonstrably affect brain NAD+ or neuro-ophthalmic measures in early human work.
However, no NAD+ precursor currently has robust, long‑term human data proving it slows normal brain aging or clearly prevents/halts common neurodegenerative diseases, so any use right now is best viewed as experimental or adjunctive rather than established therapy.
I agree.
right
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