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I’d stay away from tramadol, but note this study shows an association, but it seems reasonable.

For every year, there appears to be a 16-22% likelihood of seizures, regardless of antidepressant, with tramadol.

1 posted on 10/12/2025 2:34:45 PM PDT by ConservativeMind
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2 posted on 10/12/2025 2:35:33 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Bkmk


3 posted on 10/12/2025 2:45:34 PM PDT by sauropod
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To: ConservativeMind

I don’t think there’s even opioids in tramadol. It’s how it works in the brain. Seems Anti-depressants taken with tramadol may lead to serotonin syndrome ?
But, I agree with you, it’s a med one shouldn’t take unless it’s for a short time.


4 posted on 10/12/2025 2:49:43 PM PDT by HollyB
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To: ConservativeMind

When I see these ads for a drug and they say: “Don’t take this medicine if you’re allergic to it”, I think that might be a good idea, but how does one know beforehand?


5 posted on 10/12/2025 3:08:28 PM PDT by kawhill ("And we'll do what we must, and we'll cry without making a sound". Corbin, John)
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To: ConservativeMind

Thanks! I had a horrible case of gout this last week in my left ankle. I thought about taking some Tramadol I had a script for, but decided against it. The Colchicine I took was bad enough. At least I can stand on it now.


6 posted on 10/12/2025 3:20:05 PM PDT by OftheOhio (never could dance but always could fight - Romeo company)
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To: ConservativeMind

in addition to being a semi-synthetic opioid, tramadol also has powerful SNRI anti-depressant effects as well; thus combining with ANOTHER anti-depressant doesn’t sound like a great idea ...


7 posted on 10/12/2025 3:50:12 PM PDT by catnipman ((A Vote For The Lesser Of Two Evils Still Counts As A Vote For Evil))
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To: ConservativeMind

When I injured my back at work, the worker’s comp doctor prescribed tramadol. Might as well have prescribed a placebo. It did absolutely nothing for my pain. My regular doctor prescribed Norco, which is a true opioid. I took very little of it, (thank God I don’t have an addictive personality) but at least it relieved my pain. I still have a script for it. It takes me about 2 1/2 years to use up a 7 day supply.


10 posted on 10/12/2025 4:17:12 PM PDT by Flaming Conservative ((Pray without ceasing))
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To: ConservativeMind

I take Tramadol every once in a blue moon. I think I’ll wait for more studies before taking any more.


11 posted on 10/12/2025 4:17:21 PM PDT by gitmo (If your theology doesn’t become your biography, what good is it?)
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To: ConservativeMind
For every year, there appears to be a 16-22% likelihood of seizures, regardless of antidepressant, with tramadol.

How does that square with the text stating that the differential is 22 versus 20 per 100 person years?

BTW, I never thought tramadol was a terribly effective pain reliever, anyway.

14 posted on 10/12/2025 4:47:05 PM PDT by Pearls Before Swine
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To: ConservativeMind

Tramadol is evil. Stole 4 years from me.


16 posted on 10/12/2025 6:20:35 PM PDT by Delta 21 (None of us are descendants of fearful men!)
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