Posted on 10/11/2025 8:21:14 PM PDT by ConservativeMind
According to research, high glucose levels may serve as a biomarker indicating a worse outcome in patients who have experienced their first acute myocardial infarction.
The study demonstrated that glycemic variability, particularly glycemic delta, is associated with the size of the infarction and a reduction in left ventricular ejection fraction (LVEF). LVEF shows the strength of the heart's contraction; if it is reduced, heart failure may result.
Based on a sample of 244 individuals, the study concluded that higher glycemic delta is associated with worse myocardial damage, regardless of whether the patient has diabetes. Glycemic delta is obtained by calculating the admission blood glucose level (measured upon arrival at the hospital) minus the estimated average blood glucose level for the previous months, based on glycated hemoglobin obtained through a blood test.
To evaluate muscle loss and heart damage, a magnetic resonance imaging scan was performed 30 days after the heart attack.
"Through a simple, inexpensive test that almost all patients do, which is glycated hemoglobin for hospital admission, we end up with an easy-to-obtain biomarker with important implications. In other words, patients with a higher delta will have greater infarct mass and will need myocardial protection, both in relation to blood glucose and—for example—the use of beta-blockers to improve their prognosis," says Fonseca.
The sample included patients over 18 years of age who received fibrinolytics (medication that dissolves the thrombus causing the heart attack) within six hours of the onset of symptoms. Some of the patients had diabetes, some had prediabetes, and some did not have diabetes.
The "gold standard" treatment for myocardial infarction initially includes primary angioplasty and fibrinolysis induction.
Among the patients undergoing pharmacoinvasive treatment, the greatest glycemic delta was associated with a larger infarct and lower LVEF.
(Excerpt) Read more at medicalxpress.com ...
Doctors can now use this as a new rule of thumb they never had before.
Bump. Thanks for posting.
Bkmk
Started wearing a glucose meter 90 days ago due to pre-diabetes diagnosis and its been eye opening. I’ve lost 30 lbs and experimenting with different foods have been interesting. Had too many tater tots yesterday and got up to 250 on the meter and felt like crap. Told my wife how many times have I had a cheeseburger with fries and a couple cookies. Now I have too many tater tots and it rocked how I felt.
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