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Posted on 10/10/2025 5:15:53 PM PDT by ConservativeMind
Adequate folate consumption is recommended for women in preconception and pregnancy to ensure cell growth and development. But new research has revealed the need to establish a safe upper limit on consumption.
Current guidelines recommend supplementation with 400 to 500 micrograms (µg) of folic acid daily, starting at least one month prior to conception and continuing through the first trimester, to reduce the risk of neural tube defects such as spina bifida.
Dr. Tanja Jankovic-Karasoulos has found excess maternal folate levels—caused by the dual impact of folic acid (FA) food fortification and higher-than-recommended supplementation doses during pregnancy—can be linked to a rise in gestational diabetes mellitus (GDM).
The folate levels of more than 2,000 women pre-fortification and post-fortification were analyzed at Flinders University as part of the study, which was published in the journal Nutrients.
"Our study shows that excess maternal folate significantly increases GDM risk in our post-fortification pregnancy cohort," says Dr. Jankovic-Karasoulos.
"We suspect that increased FA intake over the past 10 to 15 years is contributing to the steady rise in GDM prevalence in Australia."
The incidence of gestational diabetes in Australia has more than tripled from 5.6% of women in 2010 to 19.3% in 2022.
"The placenta is central to regulating maternal glucose tolerance in pregnancy, so we need to understand how high FA intake affects placental function and, in turn, insulin resistance and gestational diabetes risk," says Dr. Jankovic-Karasoulos.
Researchers emphasize the importance of adequate folate in pregnancy but highlight the need to establish a safe upper limit of FA intake and to improve guidelines on FA supplementation during pregnancy which would protect the fetus right at the beginning of gestation against neural tube defects but also protect the mother and fetus from adverse effects of high blood glucose.
(Excerpt) Read more at medicalxpress.com ...
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It seems to interfere with glucose and insulin.
Too little = spina bifida, What’s a mother to do?
Some babies cannot handle folic acid at all. In fact, it undoes the nutrition provided by folate.
Look up MTFR mutation.
If you are a carrier, you might want to move to non-processed bread/rice, foreign bread/rice that does not add it, or the rare product that adds more expensive folate instead.
Yea Thalidamide!
Doctors, please stop trying to help pregnant women!
Yea Estrogen for hot flashes!
Doctors, stop helping women.
Yea acetominophen....
Bkmk
After my dad died, he left behind some folic acid tablets. My brother and I tried some and both of us felt like someone turned up our emotions.
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