Not so sweet: Some sugar substitutes linked to faster cognitive decline

Medical Xpress / American Academy of Neurology / Neurology ^ | Sept. 3, 2025 | Natalia Gomes Gonçalves et al / Thomas Monroe Holland

[ConservativeMind]

They did not find the brain aging link in people over 60–just under that age.

The artificial sweeteners examined in the study were aspartame, saccharin, acesulfame-K, erythritol, xylitol, sorbitol and tagatose.

Tagatose was the only one that had no problems, but that is a hard sweetener to find right now.

[ConservativeMind]

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[CondoleezzaProtege]

Use honey or the real cane stuff…

IN MODERATION.

[TBP]

What was this about again?

[C210N]

I’m using either liquid stevia or allulose.

Allulose is an interesting one, so-called “rare sugar”. Not being a concentrate, it is substituted 1:1 for powdered sugar.

[nickcarraway]

People will do anything to protect these substances.

[nickcarraway]

People will do anything to protect these substances.

[nickcarraway]

People will do anything to protect these substances.

[CaptainK]

I’ve never found a sugar substitute that didn’t leave an awful aftertaste.

[Java4Jay]

Monk Fruit Sweeter works good

[Dr. Sivana]

Monk Fruit and Stevia are not artificial. I am surprised that Sucralose was not included in the study.

[C210N]

I make a distinction between liquid and powdered stevia - the latter typically with erythritol, to determine the degree of being natural or artificial sweeteners.

[BradyLS]

I was going to say something funny about short-term memory loss, but I forgot what it was. :-[

[Reeses]

I am surprised that Sucralose was not included in the study.

Or plain sugar for that matter, the sugar daddy of death.

[piasa]

Was the study paid for by the manufacturer of tagatose?

[higgmeister]

Too funny!   They didn't even tested Sucralose because they knew that it couldn't cause cognitive decline because it is produced by chlorination of sucrose, selectively replacing three of the hydroxy groups—in the C1 and C6 positions of the fructose portion and the C4 position of the glucose portion.

Table salt is Na-Cl, and Sucralose is C12-H19-Cl3-O8.   No big deal.

[bigbob]

It’s all bad. I have a real sweet tooth and after reading our new Surgeon General Dr. Casey Means book (if the damn Senate would please confirm her!), I’ve given up nearly all of it. It takes a willingness to try new things and adapt but was much easier than I expected. Losing 20 pounds and bringing cholesterol numbers below normal is the payoff.

Read “Good Energy” and you’ll know what MAHA is based on.

[Dr. Sivana]

powdered stevia - the latter typically with erythritol

We use "Stevia Select", which is 100% Stevia. You must use a tiny spoon for a cup of coffee, like the old McDonald's coffee spoons before they were used for cocaine.

[nickcarraway]

Who am I?

[mlo]

The cane stuff is no healthier.

Poison in moderation is still poison. In this case, the damage is cumulative over time.