Fentanyl (rotate image mentally 180 degrees and compare to image below)
7-Hydroxymitragynine
Morphine
Diazepam - a benzodiazepine
7-Hydroxymitragynine
Morphine
Diazepam - a benzodiazepine
Tried the plant years ago... very little effect. Never t4ied the concentrate though. Used to be you could buy it off Amazon (the leaf, not the concentrate)-
Another product I think was wild celery
WIKI
Mitragyna speciosa is a tropical evergreen tree of the Rubiaceae family (coffee family) native to Southeast Asia. It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, where its dark green, glossy leaves, known as kratom, have been used in herbal medicine since at least the 19th century. They have also historically been consumed via chewing, smoking, and as a tea. Kratom has opioid-like properties and some stimulant-like effects.
kratom has been used in traditional medicine. The leaves are chewed to relieve musculoskeletal pain and increase energy, appetite, and sexual desire in ways similar to khat and coca.
While some literature reviews claim that kratom has less potential for dependence or overdose than traditional opioids, other reviews note that kratom withdrawal itself can still be quite severe.[35]
In 1836, kratom was reported to have been used as an opium substitute in Malaysia. Kratom was also used as an opium substitute in Thailand in the 19th century.
At low doses, kratom produces euphoric effects comparable to those of coca. At higher doses, kratom produces opioid-like effects.
In Thailand, a 2007 survey found that the lifetime, past year, and past 30 days kratom consumption rates were 2.32%, 0.81% and 0.57%, respectively, among respondents aged 12–65 years, and that kratom was the most widely used recreational drug in Thailand.
Kratom may be mixed with other psychoactive drugs, such as caffeine and codeine. Starting in the 2010s, a tea-based cocktail known as “4×100” became popular among some young people across Southeast Asia and especially in Thailand. It is a mix of kratom leaves, cough syrup, Coca-Cola, and ice. Around 2011, people who consumed the cocktail were often viewed more negatively than users of traditional kratom, but not as negatively as users of heroin. As of 2012, use of the cocktail was a severe problem among youth in three provinces along the border of Malaysia and southern Thailand.
https://en.wikipedia.org/wiki/Mitragyna_speciosa
35. Stanciu CN, Gnanasegaram SA, Ahmed S, Penders T (January 2019). “Kratom Withdrawal: A Systematic Review with Case Series”. Journal of Psychoactive Drugs. 51 (1): 12–18. doi:10.1080/02791072.2018.1562133. ISSN 2159-9777. PMID 30614408. S2CID 58643707.
Politicians bowing to pharmaceutical companies. They would rather them be drugged at a better profit. My SIL uses it for back pain, and he goes to work and carries on in his daily responsibilities of raising my 4 grandchildren. I assume he self regulates like human beings are capable of.
I don’t see Kratom addicts living on the street looking like zombies... strike that, as LITERAL Zombies.
grok3:
Yes, 7-hydroxymitragynine (7-OH-MIT), a potent alkaloid found in kratom, has a significant potential for addiction. It acts as a partial agonist at μ-opioid receptors, with a potency estimated to be 13-40 times greater than morphine, contributing to its rewarding and opioid-like effects. Preclinical studies show that rats can acquire self-administration of 7-OH-MIT, indicating reinforcing properties, and high doses (e.g., 3.2 mg/kg) were aversive in intracranial self-stimulation (ICSS) procedures, suggesting complex reward dynamics. Human reports on X describe rapid tolerance, physical dependency, and severe withdrawal symptoms, often worse than those of traditional opioids like oxycodone or heroin, particularly with frequent dosing due to its short half-life (1-4 hours).
Chronic use of concentrated 7-OH-MIT products can lead to addiction, tolerance, and withdrawal, with some users reporting a cycle of dependency driven by the need to avoid withdrawal. However, within whole kratom leaf or extracts, 7-OH-MIT may produce milder withdrawal compared to classical opioids, likely due to lower concentrations and the presence of other alkaloids like mitragynine.
The FDA has raised concerns about kratom-related substance use disorder, noting cases of cravings and continued use despite adverse effects.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC7542979/)[](https://en.wikipedia.org/wiki/7-Hydroxymitragynine)[](https://www.acslab.com/kratom/7-hydroxymitragynine-kratoms-minor-alkaloid)
System: I noticed you cited multiple sources in your response about 7-OH-MIT’s addictive potential. Could you clarify which specific claims are supported by which sources? I want to ensure I understand the evidence behind each point.
System: Let me break down the specific claims in my response about the addictive potential of 7-hydroxymitragynine (7-OH-MIT) and tie them directly to the sources that support each point. I’ll list each claim and indicate which web or X post references provide the evidence.
1. **Claim**: 7-OH-MIT is a potent alkaloid found in kratom, acting as a partial agonist at μ-opioid receptors with a potency 13-40 times greater than morphine, contributing to its rewarding and opioid-like effects.
- **Sources**:
- ****: States that 7-OH-MIT is approximately 13 times more potent than morphine and acts on mu-opioid receptors, supporting its potent opioid-like properties.[](https://www.acslab.com/kratom/7-hydroxymitragynine-kratoms-minor-alkaloid)
- ****: Notes that 7-OH-MIT is considered 13-40 times more potent than morphine at opioid receptors, contributing to rapid-onset analgesia and euphoria.[](https://www.thegreendragoncbd.com/blog/mitragynine-pseudoindoxyl-vs-7-hydroxymitragynine)
- ****: Confirms that 7-OH-MIT is 30-40 times more potent at opioid receptors and produces opioid-like effects such as euphoria and analgesia.[](https://www.medscape.com/viewarticle/legal-morphine-rise-kratom-and-7-oh-us-2025a1000cco)
2. **Claim**: Preclinical studies show that rats can acquire self-administration of 7-OH-MIT, indicating reinforcing properties.
- **Sources**:
- ****: References a study (Hemby et al., 2019) showing that rats acquire self-administration of 7-OH-MIT, suggesting reinforcing properties and potential abuse liability.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC7542979/)
- ****: Notes that in a rat model, rats preferred 7-OH-MIT over mitragynine in a dose-dependent manner similar to morphine, indicating reinforcing effects.[](https://pharmacy.uconn.edu/course/kratom/)
3. **Claim**: High doses of 7-OH-MIT (e.g., 3.2 mg/kg) were aversive in intracranial self-stimulation (ICSS) procedures, suggesting complex reward dynamics.
- **Sources**:
- ****: States that a high dose of 7-OH-MIT (3.2 mg/kg) increased brain reward thresholds in the ICSS procedure, indicating aversive effects at high doses.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC7542979/)
- ****: Reinforces that a high dose of 7-OH-MIT is aversive in the ICSS procedure, contrasting with morphine’s rewarding effects at intermediate doses.[](https://www.sciencedirect.com/science/article/abs/pii/S0376871620304002)
4. **Claim**: Human reports on X describe rapid tolerance, physical dependency, and severe withdrawal symptoms, often worse than those of traditional opioids like oxycodone or heroin, particularly with frequent dosing due to its short half-life (1-4 hours).
- **Sources**:
- ****: A user (@TheGoblinnn) describes 7-OH-MIT as having “unbelievable addictive potential,” highlighting rapid dependency.
- ****: Notes that 7-OH-MIT is “way more addictive than percs” with “trash” withdrawal symptoms, comparing it to Dilaudid due to its short half-life.
- ****: Reports that 7-OH-MIT withdrawals feel worse than oxycodone after prolonged use.
- ****: Mentions that 7-OH-MIT is “100% just as addictive” with withdrawals, emphasizing its addictiveness for pain management users.
- ****: States that 7-OH-MIT withdrawals are worse than heroin, with a short half-life (1-4 hours) necessitating frequent redosing.
- ****: Highlights rapid tolerance and physical dependency with 7-OH-MIT, describing a cycle of dependency to avoid withdrawal.
5. **Claim**: Chronic use of concentrated 7-OH-MIT products can lead to addiction, tolerance, and withdrawal, but within whole kratom leaf or extracts, 7-OH-MIT may produce milder withdrawal compared to classical opioids due to lower concentrations and the presence of other alkaloids like mitragynine.
- **Sources**:
- ****: Notes that concentrated chronic use of 7-OH-MIT isolate can cause addiction, tolerance, and withdrawal, but within whole kratom leaves and extracts, it appears to have milder withdrawal symptoms and lower addiction risk compared to classical opioids.[](https://www.acslab.com/kratom/7-hydroxymitragynine-kratoms-minor-alkaloid)
- ****: Discusses kratom-related substance use disorder, with 7-OH-MIT contributing to cravings and withdrawal, but suggests that whole kratom products may have a different profile due to lower 7-OH-MIT concentrations and other alkaloids.[](https://www.medscape.com/viewarticle/legal-morphine-rise-kratom-and-7-oh-us-2025a1000cco)
- ****: Indicates that 7-OH-MIT has greater abuse potential than mitragynine, with preclinical studies suggesting reinforcing effects, but traditional kratom products (with lower 7-OH-MIT) have a more balanced receptor interaction.[](https://pharmacy.uconn.edu/course/kratom/)
6. **Claim**: The FDA has raised concerns about kratom-related substance use disorder, noting cases of cravings and continued use despite adverse effects.
- **Sources**:
- ****: Reports FDA concerns about kratom-related substance use disorder, including cases of cravings, prolonged use, and withdrawal symptoms, particularly linked to 7-OH-MIT’s high potency.[](https://www.medscape.com/viewarticle/legal-morphine-rise-kratom-and-7-oh-us-2025a1000cco)
These sources collectively provide a robust foundation for the claims made. The web sources offer scientific and regulatory perspectives, while the X posts reflect real-world user experiences, though they are anecdotal and treated as inconclusive. Let me know if you’d like further clarification or details on any specific point or source!
Release the Kratom again!