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To: Myrddin
Myrddin, didn't you have an ampullary adenocarcinoma, which is a cancer of the ampulla of Vater? If so, the studies I've been looking at officially classify that as “periampullary cancer.”

The main article I used (“Molecular pathways in periampullary cancer: An overview” ($27.95)) included ampullary cancer:

Periampullary adenocarcinoma (PAC) arises in the area surrounding Ampulla of Vater.It accounts for approximately 0.5–2% of all gastrointestinal malignancies and 20% of all tumors of the extrahepatic biliary tree [[1], [2], [3]](It includes tumors of heterogenous origin which are anatomically closely related and have a similar clinical presentation, itis anatomically categorized into tumors originating in the head of the pancreas (60%), the ampulla of Vater (20%), distal common bile duct (10%), and the duodenum (10%) [4].Ampullary carcinoma is the second most common type of periampullary malignancy and represent approximately 10% of cancers resected via Whipple's procedure (pancreaticoduodenectomy) [5,6]. The incidence of PAC is higher in men (0.7 in 100,000) as compared to women (0.4 in 100,000) and is mostly seen in older patients with the tumors rarely occurring before the age of 50 years

From a snip of a recent International Hepato-Pancreato-Biliary Association HPB Journal article, “Long-term survival after minimally invasive resection versus open pancreaticoduodenectomy for periampullary cancers: a systematic review, meta-analysis and meta-regression:”

Definitions
Periampullary cancers were defined as cancers arising within 2 cm of the major papilla in the duodenum, encompassing four different types of cancers: (i) ampullary (ampulla of Vater); (ii) biliary (intrapancreatic distal bile duct); (iii) pancreatic (head–uncinate process) and (iv) duodenal (mainly from the second portion).17,18

https://www.sciencedirect.com/science/article/pii/S1365182X20311825

If you had ampullary cancer (cancer of the ampulla of Vater), my research holds for you.

65 posted on 07/29/2025 12:50:19 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
My tumor invaded in both directions from the Ampulla. Tumor invades into muscularis propria of the duodenum, directly invades pancreas (up to 0.5cm)

There were 3 histological stains performed on the tumor. Stains were MUC1 (positive), CK20 (positive), CDX2 (weak). Morphologically, the ampullar tumor appears to be pancreatobiliary type. Adenocarcinoma invading from the Ampulla of Vater directly into the pancreas.

The above text extracted from the pathology report. I read the linked report below last year. The principal focus of that report was comparing MIPD (laparoscopic, robotic) to OPD (open PD). Mine was OPD. The paper demonstrates the difficulty of performing a meta-analysis on a broad set of papers and just how much has to be "tossed" because it isn't trustworthy for various reasons.

I spent considerable time with ChatGPT and grok3 entering all of the fine details of my experience last year. My weight loss (161 -> 136), multiple post-operative infections and histology data pushed me to the 23% end of the 23% to 67% 5 year survival. The multiple CT scans also uncovered a abdominal aortic aneurysm that is inoperable and likely to take me out before a recurrence of the cancer. It has been an "interesting" year.

66 posted on 07/29/2025 3:52:25 PM PDT by Myrddin
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