Minimally invasive disc injection reduces pain and improves function in chronic back pain, feasibility study finds

Medical Xpress / Phys.org / BMC Musculoskeletal Disorders ^ | May 8, 2025 | Justin Jackson / Douglas P. Beall et al

[ConservativeMind]

VIVEX Biologics, Inc. sponsored research reports positive outcomes for patients with chronic lumbar discogenic pain treated using a single intradiscal injection of VIA Disc NP, an allogeneic nucleus pulposus product derived from cadaveric disc tissue.

Researchers conducted a prospective, single-arm clinical study at six U.S. sites to assess the impact of intradiscal injection of VIA Disc NP on back pain severity and functional impairment in patients with chronic lumbar discogenic pain unresponsive to conservative management.

A total of 28 adults were enrolled, with 22 participants completing the 12-month follow-up. Patients received a single injection of 100 mg of VIA Disc NP. Under fluoroscopic guidance, the product was delivered into targeted lumbar discs (L1-S1) through a spinal needle, with patients discharged the same day. Follow-up assessments occurred.

Study participants experienced a 43% reduction in back pain severity from baseline to 12 months.

Numeric Rating Scale (NRS) scores, a self-reported measure of pain intensity ranging from 0 (no pain) to 10 (worst possible pain), decreased from 7.1 at baseline to 3.8 at 12 months; 64% of participants achieved at least a 30% reduction in pain severity, and 55% reported a reduction of 50% or greater.

Nearly 60% of participants reported a pain severity score of 3 or less at 12 months, meeting the patient acceptable symptom state (PASS) threshold, which indicates a pain level perceived as manageable by the patient.

Oswestry Disability Index (ODI) scores, a standardized measure of disability related to low back pain that assesses functional impairment across daily activities, decreased by 50% from baseline to 12 months. Some 59% of participants achieved a clinically significant improvement in functional impairment, defined as a reduction of at least 30% from baseline. Severe or crippled impairment decreased from 82% of participants at baseline to 18% at 12 months.

[doorgunner69]

I sure hope they work and last a while.

Almost as scary as the first injection up the spine

[Flaming Conservative]

RF ABLATIONS, not abortions. Sheesh, sometimes I hate autocorrect.

[Delta 21]

Its made from other people's bones! So you can eat it and feel better from eating people!