What’s weird is that I am right-handed, but I play guitar (badly!) left-handed, it was a real bear to find a left-handed guitar.
Hendrix just played upside down.
Give us some “Little Wing”
I’m left-handed and play right-handed. It feels completely natural. I don’t sweat it. I like using my dominant hand for fretting. There are lots of left-handed guitars now, though.