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Implant-derived metals found in cerebrospinal fluid
Medical Xpress / JAMA Network Open ^ | April 1, 2025 | Justin Jackson / Anastasia Rakow et al

Posted on 04/05/2025 10:17:26 PM PDT by ConservativeMind

Research has found that metal particles from artificial joint implants can enter the central nervous system and accumulate in cerebrospinal fluid, raising concerns about potential neurological effects.

Modern implants are designed for durability.

Over time, wear and corrosion of these materials can release microscopic particles into surrounding tissue.

Emerging concerns point to the possibility of metal particles entering the bloodstream and affecting organs far from the implant.

In the study, researchers conducted a single-site cross-sectional study to determine whether metals from joint implants can be found in cerebrospinal fluid and bloodstream.

Cobalt levels in cerebrospinal fluid were significantly higher in patients with joint implants than in matched controls. Strong correlations were observed between cobalt levels in cerebrospinal fluid and those in serum and whole blood, suggesting systemic exposure may be reaching the central nervous system.

Patients with implants also exhibited higher levels of chromium, titanium, niobium, and zirconium in blood and serum. In cerebrospinal fluid, titanium, niobium, and zirconium levels were significantly elevated, but only when serum levels of these metals were also increased.

Patients with implant components containing cobalt-chromium-molybdenum alloys had the highest cerebrospinal fluid concentrations of both cobalt and chromium. Cobalt levels in cerebrospinal fluid were significantly elevated even among patients with implants in place for less than ten years. Pain in the joint containing the implant was also associated with higher cobalt levels in cerebrospinal fluid.

No increase in cerebrospinal fluid metal levels was observed in patients with implants lacking cobalt-chromium-molybdenum components. Patients with cemented implants showed elevated levels of zirconium in blood and serum, though not in cerebrospinal fluid. Aluminum did not appear elevated in the implant group despite being present in certain implant alloys.

Findings indicate that metal particles released from joint implants can accumulate in the central nervous system, especially those containing cobalt-chromium-molybdenum.

(Excerpt) Read more at medicalxpress.com ...


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To: Larry Lucido

Lol I did too- not sure what the correct line is- I got that off a site that posts lyrics- but they might have it wrong too, I dunno


21 posted on 04/06/2025 5:56:08 AM PDT by Bob434 (Time flies like an arrow, fruit flies like a banana)
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To: Bob434

No, I’m pretty sure you had it right. I think that just falls under the category of misheard lyrics. :)


22 posted on 04/06/2025 6:10:36 AM PDT by Larry Lucido (Donate! Don't just post clickbait!)
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To: Larry Lucido

Hendricks “kiss the sky” is another misheard lyric lol some songs,are pretty funny with their misheard lyrics


23 posted on 04/06/2025 6:19:36 AM PDT by Bob434 (Time flies like an arrow, fruit flies like a banana)
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To: Bob434

I just now read that in live performances, Jimi Hendrix would sing the lyrics kiss this guy on purpose just to mess with the audience.


24 posted on 04/06/2025 6:27:24 AM PDT by Larry Lucido (Donate! Don't just post clickbait!)
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To: Larry Lucido

Lol I wouldn’t doubt it- probably a lot of singers did that too after learning how audiences would mishear the lyrics.


25 posted on 04/06/2025 6:28:39 AM PDT by Bob434 (Time flies like an arrow, fruit flies like a banana)
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To: ConservativeMind
Nothing new here, metal ion release from implants has been a serious concern since the 1980s. And it's not just from wear, it's from the ions chemically leaching out of the metal itself

Most hip implants these days have moved to titanium and the use of ceramic and polymer wear surfaces for just this reason

26 posted on 04/06/2025 6:30:35 AM PDT by rdcbn1 (TV )
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To: Palio di Siena

Ditto. Both of my knees were replaced four years ago. They are a huge improvement. I could not walk more than one hundred yards without nauseating bone on bone pain. Now, my walking range is painless and unlimited. However, I believe that the surgeon’s skill is the critical favor, as one knee is slightly better than the other.


27 posted on 04/06/2025 6:57:13 AM PDT by PUGACHEV
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