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Sleep problems; I saw something about Melatonin and Pineal Calcification and thought it dubious. I looked it up and its apparently real especially as you age. So in addition to the things previously mentioned, Calcium deposits can reduce Melatonin production and interfere with sleep and circadian rhythm. (Great...another problem to worry about while getting old!)

Pineal Calcification

Snip...."Based on these results, we speculated that a more suitable way to preserve a healthy and functional pineal gland is either to retard its calcification or to recover the functions of the calcified gland. As mentioned, several pathological conditions might promote the premature pineal calcification. However, the environmental biohazards may also contribute to its development. One of them is fluoride. It was reported that the pineal gland in goosander concentrates fluoride which is a water pollutant [290]. The level of fluoride in the pineal gland of goosander was 5-fold higher than that it in the brain of the animal. The similar results were observed in the aged human pineal gland. In addition, the high level of fluoride in the human pineal gland is positively related to its calcium accumulation of the gland [291]. Thus, decrease in environmental fluoride pollution may be helpful in delaying or avoiding premature pineal calcification. It was hypothesized that the lack of calcium salt crystallization inhibitors, such as pyrophosphate and phytate, would favor calcification [292]. Studies indicated that the phytate content in brains of healthy animals was 10-fold higher than that in other tissues [293,294]. Increases in the availability of calcium salt crystallization inhibitors would tend to protect against pathological pineal calcification." ....snip....

Accumulating evidence indicates that pineal health is important to preserve the optimal physiological status of animals, including humans. The pineal gland is a unique organ which synthesizes melatonin as the signaling molecule of natural environmental changes and as a potent neuronal protective antioxidant. This gland undergoes calcification due to its anatomic structure (rich in vasculature and blood flow) and functions (melatonin production and CSF generation). The pineal has the highest calcification rate among all organs and tissues. Pineal calcification jeopardizes the melatonin synthetic capacity of this gland and is associated with a variety of neuronal diseases."

***I do not know what "goosender" is. I suspect its some sort of document wide autocorrect error? (Goose dander???)