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Surgical approach has 'significant impact' on treatment of Crohn's disease
Medical Xpress / University of Limerick / Gastroenterology ^ | Feb. 18, 2025 | Ming Duan et al

Posted on 02/23/2025 10:19:53 AM PST by ConservativeMind

A surgical approach pioneered in Ireland could have a global impact on the treatment of Crohn's disease.

A new study has shown that the approach first developed in Ireland could have a major impact on treating Crohn's disease.

Crohn's disease is incurable, with high rates of recurrence, even after surgery. It is a condition for which at least 80% of patients will require surgery to treat at some point.

To add to this, around 40% of those will require repeat surgery.

However, the new approach pioneered at UL and UHL dramatically reduces the possibility that follow-up surgery will be needed to as few as approximately 4% of patients.

The new surgical approach requires removal of the mesentery—which was reclassified as a new organ following discoveries by Professor Coffey's team and collaborators in 2016. It builds on the scientific advances the group made on the mesentery, an organ in which all digestive organs of the abdomen develop and then remain connected to.

The new study shows that removal of the mesentery reduces recurrence of Crohn's disease in the inner lining of the intestine—called endoscopic recurrence.

The research looked at relapse of Crohn's disease in the inner lining of the intestine, which generally occurs very quickly after initial surgery for the disease.

The randomized control trial found that patients who had conventional surgery tended to suffer high rates of relapse, but that patients who had surgery performed using the new approach, had lower relapse rates—from around 46% down to just 23% of patients.

The trial also looked at the severity of relapse in the inner lining and found that for each grade of severity, relapse was reduced in patients in whom the mesentery was also removed.

The results indicate strong support for including removal of the mesentery during surgery for Crohn's disease.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: crohnsdisease
This approach reduces the likelihood of a repeat surgery for Crohn’s disease from 40% to 4% - 23%.
1 posted on 02/23/2025 10:19:53 AM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 02/23/2025 10:20:27 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

” the mesentery, an organ in which all digestive organs of the abdomen develop and then remain connected to.”

Now that’s something new. Never heard that before. It sounds like a vestigial organ like the appendix and the cocyx remnant of the vestigial tail.


3 posted on 02/23/2025 10:25:18 AM PST by ProtectOurFreedom (Democrats who say ‘no one is above the law’ won’t mind going to prison for the money they stole.)
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To: ProtectOurFreedom

I can’t see that it’s not synonymous with the peritoneum, which is big baggie or envelope with the abdominal organs inside. It holds them in place for one thing.


4 posted on 02/23/2025 11:36:17 AM PST by sopo
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To: sopo

inflammation of the peritoneum is call peritonitis. It’s a similar concept anatomically to the membrane enveloping the lungs in the chest cavity, called the pleura, inflammation called pleuritis.Or the pericardium enveloping the heart.


5 posted on 02/23/2025 11:41:23 AM PST by sopo
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To: ConservativeMind

Pretty sig decrease- wish it had. Even around d 50 years ago.


6 posted on 02/23/2025 11:43:53 AM PST by Bob434 (...Time flies like an arrow, fruit flies like a banana)
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To: ConservativeMind

Very interesting.


7 posted on 02/23/2025 12:47:50 PM PST by telescope115 (I NEED MY SPACE!!! 🔭)
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To: ConservativeMind

My son had some intestine removed to treat his Crohn’s Disease. He hasn’t been bothered much since.

He’s a trucker and doesn’t let it limit him. He’s considering joining the police force.


8 posted on 02/23/2025 6:52:37 PM PST by cyclotic (Don’t be part of the problem. Be the entire problem)
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