Interesting thesis. I’m wondering what they regard as the causes of this “mitochondrial damage.”
My guess:
Climate Change.....................
Humans can become “sugar burners”, even at the mitochondrial level. Cells show a clear preference for burning glucose. The pathways for for the uptake and reregulation for burning fatty acids become atrophied with disuse.
This is probably why intermittent fasting, and calorie restriction, low-carb works so effectively. Critics say “starving yourself” but it isn’t starving, it forces the body to relearn how to do something it is intended to do - burn fat for energy. There is only one organ in the human body that requires glucose, the brain, and our bodies can synthesize all that is required from fat. Imagine that.
YOUR QUESTION IS SPOT ON: EXCESS MITOCHONDRIAL IRON CAUSES THE ACCUMULATION OF EXCESS UNMATCHED ELECTRONS (REACTIVE OXYGEN SPECIES) IN THE ELECTRON TRANSPORT CHAIN IN THE PRODUCTION OF ENERGY (ATP). THIS PHENOMENA HAS BEEN WELL PUBLISHED FOE 20 YEARS. I REPRESENT MULTIPLE GRANTED PATENTS ON THIS SUBJECT MATTER.