Study shows zoledronate prevents morphometric vertebral fractures over 10 years (~40% less risk)

Medical Xpress / HealthDay / New England Journal of Medicine ^ | Elana Gotkine / Mark J. Bolland et al / Roland Chapurlat

[ConservativeMind]

For early postmenopausal women, zoledronate administered at baseline and five years is effective for preventing morphometric vertebral fracture, according to a study.

Mark J. Bolland, M.B., Ch.B., Ph.D. and colleagues conducted a 10-year prospective double-blind trial involving early postmenopausal women (age 50 to 60 years) with bone mineral density T scores lower than 0 and higher than −2.5 at the lumbar spine, femoral neck, or hip.

Participants were randomly assigned to receive an infusion of zoledronate (5 mg) at baseline and at five years (zoledronate-zoledronate group), zoledronate (5 mg) at baseline and placebo at five years (zoledronate-placebo group), or placebo at both baseline and five years (placebo-placebo group).

Overall, 1,003 of the 1,054 women completed 10 years of follow-up. The researchers found that 6.3, 6.6, and 11.1 percent of women in the zoledronate-zoledronate, zoledronate-placebo, and placebo-placebo groups, respectively, had a new morphometric fracture (relative risks, 0.56 and 0.59 for zoledronate-zoledronate and zoledronate-placebo, respectively, versus placebo-placebo).

The relative risks of fragility fracture, any fracture, and major osteoporotic fracture were 0.72, 0.70, and 0.60, respectively, and 0.79, 0.77, and 0.71, respectively, for zoledronate-zoledronate versus placebo-placebo and for zoledronate-placebo versus placebo-placebo.

"Intravenous zoledronate administered once every five years reduced the incidence of morphometric vertebral fractures during a 10-year period," the authors write.

[ConservativeMind]

Zoledronate (Zometa) administered once every five years for ten years brought down bone fracture risk a large amount.

[ConservativeMind]

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[nagant]

DHEA does the same thing, and it’s a naturally produced human hormone.

[b4me]

What about natural stuff like calcium or vitamin D with K2 which helps put the calcium back into bones instead of allowing it to leech out?