Free Republic
Browse · Search
General/Chat
Topics · Post Article

This research specifically covered ACE-Inhibitors, but could be a problem with other renin or ARB medicines, it appears.

The title of this research paper is ominous sounding: “Transformation of the Kidney into a Pathological Neuro-Immune-Endocrine Organ.”

To be fair, the high blood pressure hurts all organs in your body, so reducing blood pressure is likely more important, but there are other approaches to do that, including diet and exercise. Soluble fiber, green tea, resveratrol, quercetin, curcumin, among other foods, are able to positively affect blood pressure.

Other drugs have their own issues, but would not likely have this same action on the kidneys.

Additionally, there are supplements that can help reverse arterial plaque, including Vitamin K2-MK4 and K1, from one amazing study.

Growing older can be tough.

1 posted on 11/24/2024 7:30:39 AM PST by ConservativeMind
[ Post Reply | Private Reply | View Replies ]


To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 11/24/2024 7:31:04 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

ACE inhibitors are the one thing that cannot take because I end up with coughing fits.


3 posted on 11/24/2024 7:34:58 AM PST by Larry Lucido (Donate! Don't just post clickbait!)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

> RAS inhibitors, which include the generics enalapril, lisinopril, ramipril and others… <

And others? Oh come on, University of Virginia. If you’re going to make an alarming statement (which well might be true), why not take a moment and give us a complete list?


4 posted on 11/24/2024 7:49:29 AM PST by Leaning Right (It’s morning in America. Again.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

I’m beginning to think there aren’t ANY drugs that aren’t bad for you.....


5 posted on 11/24/2024 7:53:37 AM PST by ducttape45 (Jeremiah 17:9, "The heart is deceitful above all things, and desperately wicked: who can know it?")
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

Sigh.

NOTHING does more damage to kidneys than uncontrolled hypertension(high blood pressure).

Please Freepers continue with your blood pressure medication and talk to your physician before you change anything.


6 posted on 11/24/2024 7:56:37 AM PST by LeonardFMason
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

For many years I’ve taken Valsartan (an ARB) and Amlodipine (a calcium channel blocker) to control my high blood pressure.

I’d like to instead try rilmenidine (currently used in parts of Europe to treat hypertension, but shown experimentally in animals at young and older ages to increase lifespan and improves health markers, mimicking the effects of caloric restriction). Unfortunately not approved for use in the US.


8 posted on 11/24/2024 7:59:44 AM PST by House Atreides (I’m now ULTRA-MAGA-PRO-MAX.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind
ConservativeMind :" Additionally, there are supplements that can help reverse arterial plaque, including Vitamin K2-MK4 and K1, from one amazing study.
Growing older can be tough."

Many thanks for your analysis, and alternative treatment substitutes , and alternative vitamins,
Very much appreciated as one is getting older, while remaining healthy, seems to be a challenge, now a days.
And Growing older can be can be a challenge."and a bi*ch" !(Emphasis Mine)

9 posted on 11/24/2024 8:01:04 AM PST by Tilted Irish Kilt
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

What IS “high blood pressure”? Used to be systolic over 150. Then 140. Now they want people of every age to be at 120. Or lower. And will prescribe drugs to get them there.

The US “trial” that lowered the number to 120 was so biased that it could only be by design. The better quality trials seem to indicate no need for medicine if systolic is under 150-160. Europe still uses 140 as the start of high blood pressure.

We take too many drugs.

Another factor: Many elderly patients end up with multiple prescriptions for blood pressure. My wife did home health care and frequently - several times a week - found a patient with 2-4 prescriptions, from different doctors, for the same blood pressure medicine. She would get it corrected but wondered how many falls took place due to artificially LOW blood pressure.


10 posted on 11/24/2024 8:12:40 AM PST by Mr Rogers
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

My doctor prescribed statins and another drug that ‘flushed’ the kidneys to prevent this side-effect. Didn’t tell me that it took cholesterol levels way down, causing brain fog. Not worth it at my age to gain maybe a day or two of life after 7 decades of living.


12 posted on 11/24/2024 8:32:47 AM PST by RideForever (Damn, another dangling par .....)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: NewJerseyJoe

P4L


13 posted on 11/24/2024 8:41:03 AM PST by NewJerseyJoe (Rat mantra: "Facts are meaningless! You can use facts to prove anything that's even remotely true!")
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

EVERY medication has side effects (some harmful, some just irritating).

The key is finding the right risk/reward ratio, and discontinuing meds when that ratio changes.

What makes sense when you’re 40 usually doesn’t at 70. I hate to see the elderly on statins, or multi drug therapyfor hypertension. Add anti dementia meds in end stage dementia where they do more harm than good.

People take on faith what they should be suspicious of. Follow the money.


14 posted on 11/24/2024 8:50:02 AM PST by clee1 (We use 43 muscles to frown, 17 to smile, and 2 to pull a trigger. I'm lazy and don't wish to smile.)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind
From ChatGPT:

In most cases, RAS inhibitors do not damage the kidneys. Instead, they are protective when used appropriately. However, they can pose risks if certain conditions arise:

•Severe volume depletion (e.g., from dehydration or diuretics).

•Bilateral renal artery stenosis (narrowing of both renal arteries).

•Advanced kidney disease with very low GFR.


15 posted on 11/24/2024 9:09:51 AM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind; LeonardFMason

https://www.google.com/search?q=RAS+inhibitors+kidney+damage

[bottom line: RAS inhibitors are generally protective of kidney function in the face of hypertension, EXCEPT for folks who already have advanced chronic kidney disease (CKD)]:

“While generally considered protective for kidneys in most patients with chronic kidney disease (CKD), in certain situations, particularly with advanced CKD, Renin-Angiotensin System (RAS) inhibitors can potentially worsen kidney function and increase the risk of kidney damage due to potential side effects like hyperkalemia and a sudden decline in renal function, requiring close monitoring when used in such cases; however, for most patients with mild to moderate CKD, RAS inhibitors are considered beneficial for slowing kidney disease progression.

Key points about RAS inhibitors and kidney damage:
Protective effect in most cases:

In individuals with mild to moderate CKD, RAS inhibitors like ACE inhibitors and ARBs are often prescribed to help slow the decline in kidney function by lowering blood pressure and reducing proteinuria (excess protein in urine).
Risks in advanced CKD:

When kidney function is significantly impaired (advanced CKD), using RAS inhibitors can increase the risk of complications like hyperkalemia (high potassium levels) and a sudden drop in kidney function, which is why careful monitoring is crucial.

Considerations for use:

Severity of kidney disease: Doctors often need to adjust dosage or discontinue RAS inhibitors in patients with very advanced CKD.

Monitoring: Regular monitoring of blood potassium levels and kidney function is essential when using RAS inhibitors in patients with CKD.

Mechanism of potential kidney damage:

While the exact mechanism is complex, some research suggests that in advanced CKD, RAS inhibition can disrupt the delicate balance of renal blood flow, potentially leading to further kidney damage in certain individuals.

Kidney Damage Caused by Blood Pressure Drugs Explained
6 days ago — Long-term management of the condition with renin–angiotensin system inhibitors can cause kidney damage for some patients...”


18 posted on 11/24/2024 9:30:16 AM PST by catnipman ((A Vote For The Lesser Of Two Evils Still Counts As A Vote For Evil))
[ Post Reply | Private Reply | To 1 | View Replies ]

To: null and void; aragorn; EnigmaticAnomaly; kalee; Kale; AZ .44 MAG; Baynative; bgill; bitt; ...

P


20 posted on 11/24/2024 10:43:02 AM PST by bitt (<img src=' 'width=30%>)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

Helps explain why people who control their blood pressure to the level demanded by the ‘medical community’ don’t seem to live any longer (or even as long) as people who are somewhat (but not excessively above) those guidelines - as the people who are not controlling BP as tightly take far less meds (usually some meds, but not nearly as much).


21 posted on 11/24/2024 10:43:52 AM PST by BobL
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind

Bad news: Eat right. Take the right medications. Get plenty of exercise. YOU WILL STILL DIE OF SOMETHING !

It’s so disappointing to obsess with a healthy lifestyle, exercise regularly, eat only healthy foods, and ultimately still find yourself in the hospital, DYING (of nothing).

There must be a tombstone somewhere with the inscription: “Being dead now anyway, I wish I had eaten a lot more french fries and greasy hamburgers.”


22 posted on 11/24/2024 10:44:55 AM PST by Gnome1949
[ Post Reply | Private Reply | To 1 | View Replies ]

To: ConservativeMind; All

MD’s are the snake oil salesmen that they accused others of being in the 1930’s - BP medicine is derived (sometimes synthesized) using the venow of a pit viper, (you know the deadliest venom known) but it does thin the blood!


23 posted on 11/24/2024 11:36:03 AM PST by BrandtMichaels ( 1st Peter 4:8 "Above all, love each other deeply because love covers a multitude of sins." )
[ Post Reply | Private Reply | To 1 | View Replies ]

Free Republic
Browse · Search
General/Chat
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson