Posted on 10/01/2024 8:19:22 PM PDT by ConservativeMind
In a study, researchers have explored the effects of circadian rhythm disruption on the lungs. They have found that nearly every cell in the body is keeping track of time.
The circadian rhythm helps synchronize the body's organ systems and regulate the immune system. If one of them goes off beat, the repercussions can affect the whole group.
Several factors influence circadian rhythm, including stress, physical activity and food intake; however, light and dark play the biggest role.
Circadian rhythm disruption occurs when the body's internal clock is out of sync with the environment. It can be caused by sleep habits, shift work or travel.
Previous research identified a link between circadian rhythm disruption and gut barrier function. Parthasarathy, a pulmonologist, wanted to know if a similar effect could be seen in the lungs.
For the study, researchers used lighting schedules to disturb the circadian rhythm of mice, essentially giving them jet lag. They also used lipopolysaccharides, which are part of the outer membrane of certain types of bacteria, to simulate acute lung injury.
When they evoked circadian rhythm disruption, the first thing they observed was an increase in acute lung inflammation due to an exacerbated immune response.
"There are more immune cells around when we are waking up and we are getting ready to go to sleep," Parthasarathy said, adding that the circadian rhythm cellular machinery also includes the parts of a cell that regulate inflammation. "This study shows just by having jet lag, your lungs might be more inflamed and more vulnerable to injury."
In addition to increased inflammation, this study marked the first time researchers were able to show increased lung permeability due to circadian disorganization and identify the gene dysregulation involved in the process.
(Excerpt) Read more at medicalxpress.com ...
bfl
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For the study, researchers used lighting schedules to disturb the circadian rhythm of mice, essentially giving them jet lag.
"Time" is one of my favorite subjects, and I saw this thread the first thing in the morning -- the eve of the Jewish new year -- as I got going for the day to see what would appear "on the menu". (Unleavened flatbread as it turns out.)
There's always a reason to find the holy within the mundane, and in this topic I discovered a big (three times) blessing:
The term circadian comes from the Latin circa, meaning "around", and dies, meaning "day".
Hebrew is a "circadian clock", sh'on tzirkadi:
שעון צירקדי
Which adds up to 840, the numeric country code for the United States. (I keep these sorts on details on-hand, just in case.)
More specifically, "circadian" [צירקדי] = 414, which very much relates to time, and involves Esther:
Esther 4:14 For if thou altogether holdest thy peace at this time [עת], then shall there enlargement and deliverance arise to the Jews from another place; but thou and thy father's house shall be destroyed: and who knoweth whether thou art come to the kingdom for such a time [עת] as this?
(Esther's father was "Avichayil", "my father is chayil" -- strength, might, valour)
And as a reference to army time, in IDF-speak the equivalent to the D-Day and H-Hour terminology is the letter ayin [ע] for the day (for the word et, time עת) and a shin [ש]
for the hour (sha'a שעה) -- yom ha-ayin and she'at ha-shin -- "ayin" day and "shin" hour.
"יום ה-ע" "שעת ה-ש"
The explanation I had found some while back was that the use of the letter ayin for a day/time (versus a yud for the word יום yom, day), was so that the abbreviation for a D-Day would not look like the name of God was in there. 🤔
The blessing comes out of collective observation because the word "circadian" not only begins with "tzir",
ציר
, the word for an axis, hinge; i.e. a pivot point (derived terms: tzir zman, timeline)...
ציר also spells "Cheer" [צ'יר], the word transliterated from English; e.g. Cheers [צ'ירס], the famous place where everybody knows your name.
Three cheers *is* the blessing, equivalent to L'chaim! L'chaim! L'Chaim!
Right on the Wiki page (horrible place, the Moab of the encyclopedia world):
("על שם הברכה המקובלת "לחיים)
"named after the customary blessing, "L'Chaim!"*
The location of three cheers [ציר x 3], therefore, is the origin point of three-dimensional space, ground 0,0,0 of the Cartesian coordinate system. The Hebrew page has the diagram in Hebrew, so you can clearly see all of the names and labels, the three cheers x, y, and z:
(The one beyond is t, time, the odd one out, the continuum not like the others. You remember the two priests who had been taken to the woodshed?)
It's all highly coordinated because the location of the Hub is Boston (because this stuff is literal) -- the place the Pilgrims envisioned as the City on a Hill and beyond, New Jerusalem, and "Boston" [בוסטון] = 133, so that's one example.
Again leading to the blessing of life, because Psalm 133 is one of three Psalms with three verses:
A Song of Maalot of David;
1. Behold, how good and how pleasant it is for brothers to dwell together in unity: 🍻
2. It is like the precious ointment upon the head, that runs down upon the beard, Aaron's beard, that runs down to the hem of his garments:
3. Like the dew of Hermon descending upon the mountains of Zion; for there [כי שם: 370, ש"ע] the Lord has commanded the blessing, life for evermore:
Psalm 133 -- the origin of the hymn.
("Purimfest 1946" fell on Saint Patriarchs er Patrick's Day, and there's nowhere like the Hub for to celebrate the shem-rock formed from the 3 heart shapes.)
It never ends, but I've observed over time that these many simple observations over time have relegated me to leper status, pretty much as the unseen subject of the "Do Not Want" meme with the dog.
That's okay, I always find the best stuff along the Way:
* עַל שֵׁם (al sheim) -- 1) So termed because. 2) For the sake of. 3) By name of; lit. on the name -- is abbreviated as ayin-shin [ע״ש], so it's not just that...
... "ayin-shin" spells a real "ash", a Setaceous Hebrew Character -- named that on account of his mirrored pair of letter nuns, and also that he's downright bristly --
It's all a mashal, משל, adding to 370 for the non-rhotic accent-speaking folks from the city, of Boston. Wheels within wheels.
Remember the boy whom Elisha had promised to the Shunamite woman? When groan, he fell while going out into the field, to his father at harvest time, exclaiming "R'oshi! R'oshi!" "My head! My head!"
It's like that doubled Rōshi. And so much more. (see Rashī, being equivalent to an old master)
Q.E.D. [מש"ל]
🏃♀️ . . . . .
(Sorry for any typos or edit oopsies. I'm OUTATIME.)
And he lived, so
Happy New Year 85! 😉
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