I worked in a scientific research organization during Covid. If I wasn’t pounding away all day ordering necessary and often very specific and esoteric supplies (and knowing from years of experience where to get the right things) everything would have stalled. I did it just fine from home.
The downside for me was that I really liked the folks I worked with, and missed seeing them every day...
I also like the people I worked with in the office for over a decade prior to Covid, and actually miss seeing them daily.
At least we now have many coming back to the office at least one day a week, so that's actually helping somewhat from several perspectives.