Yes. There is a comprehension problem -- and it's you, my friend!
Let's take a close look at your rant/comments/misstatements about the article here.
A very available, cheap blood test can tell you or your doctor that your multiple myeloma immunotherapy is working 15 days after starting it.....If it doesn’t look good at that point, immediately start a different therapy.
That's ludicrous. The treatment protocol involves the single infusion of engineered T cells back into the patient that takes place in a hospital setting and lasts for the time it takes to empty the bag that holds the infused cells.
You don't start another therapy! Get it. Please explain how you stop the infusion that lasts for minutes and then start some other from of treatment. When the infusion is complete, it's over. Done. There is no possible way to "stop and immediately start a different strategy." Your words -- not mine.
Further, CAR-T is usually followed by at least two previous treatments that have failed over months or years. You don't just stop and try another treatment -- 'cause at that point you may be out of options.
You may already get this blood test as part of your annual physical. There’s no need to wait a lot of precious months now.
There you go again! It's just another foolish statement by someone who knows not of what he speaks. Any lame-brain knows that there is a common set of blood panels taken at an annual physical. There is no way that the test described by MSK is performed by a local clinician. Don't believe me, ask your doc to run me "that there CAR-T test, will 'ya?"
Sure. I can see that conversation with my doc every year. "Now, doc, be sure you run that CAR-T test for me." HUH??
This is just more of your nonsense of misleading people on a subject that you are clueless about.
You don't start another therapy! Get it. Please explain how you stop the infusion that lasts for minutes and then start some other from of treatment. When the infusion is complete, it's over. Done. There is no possible way to “stop and immediately start a different strategy.” Your words — not mine.
Directly from the write up:
The paper found that patients who had an increase in absolute lymphocyte count (ALC) during the first 15 days after receiving a CAR-T infusion had a higher chance of a complete response and better progression-free survival than patients with a lower ALC at day 15. Knowing that the treatment may not work allows doctors to try other options more quickly.
“If doctors can identify patients who are more likely to have a poor response to BCMA CAR-T, other treatments can be explored or given earlier,” said Dr. Mejia Saldarriaga.
I never said the test was to determine that you should get CAR-T therapy. You seem to be getting that from somewhere else. I did say that a simple ALC test at 15 days determines if the CAR-T therapy you got from your doctor will work for you. Your doctor can help find other treatments. Your doctor will need to know that he can run an ALC test to determine that his CAR-T will work, or will be destined to fail, at just 15 days after the therapy. Until now, no one knew failure could be known at just 15 days. Get it?
What I am saying is straight from the write up.
It's not hard to understand, “icclearly.”