CAVEAT: This is just my personal opinion. YMMV.
At work I rely on CrowdStrike Falcon.
At home I use paid MalwareBytes. On Windows I also enable Defender.
They aren't for everyone; they're not cheap and they require some work and awareness. But they're very good, and largely non-obtrusive.
In my experience, all the big commercial packages (McAfee, etc.) are intrusive crap and not worth the price.
Thanks dayglored.