Posted on 05/07/2024 1:12:50 PM PDT by Angelino97
A young boy died in a trial for Pfizer’s experimental gene therapy for Duchenne muscular dystrophy, the company told patient advocates Tuesday.
The boy was enrolled in Daylight, a trial studying the treatment in boys aged 2 or 3. The boy had received the therapy early last year, Pfizer told the advocates in a note posted online by Parent Project Muscular Dystrophy.
Pfizer said it had not yet determined precisely what happened or whether it was linked to the treatment. Deaths and severe side effects linked to gene therapy have generally happened soon after dosing.
(Excerpt) Read more at statnews.com ...
Yes, it is a virus vector. It should only be expressed in muscle cells. It’s the gene, dystrophin, that is mutated in this disease.
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DMD is caused by an absence of dystrophin, a protein that helps keep muscle cells intact. In the absence of dystrophin, muscle cells deteriorate. Fordadistrogene movaparvovec is an investigational recombinant adeno-associated virus serotype 9 (AAV9) capsid carrying a shortened version of the human dystrophin gene (mini-dystrophin) under the control of a human muscle-specific promotor. The AAV9 capsid was chosen as the delivery mechanism because of its potential to target muscle tissue.
After further reading they didn’t use the lipid nanoparticles with this. Seems that is used primarily for RNA delivery not DNA delivery. The DNA is much more stable and probably wouldn’t require the protective lipid coat to maintain its integrity like RNA would.
Who do you suppose should make medical decisions for a small child? I think it’s usually the parents.
Well in a case like this. It was mandated on to the child. He didn’t get a choice to “opt in” or out. He is dead as a result. Just like those poor kids forced to get the fake vaxes.
Anyone submitting a person to be a guinea pig for Pfizer needs their heads examined.
I’m guessing you don’t realize what a crippling and eventualy fatal disease DMD is.
Once the damage is incurred it cant be fixed or healed. The therapy is to prevent the damage from ever happening. So it pretty much has to happen at 3-4 because that’s when it starts to manifest.
You’re comparing things that don’t ‘compare’ at all.
“ I’m just saying that I personally wouldn’t recommend mRNA injections for anything other than a fatal disease that has no other treatment options.”
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Who do you think is offered clinical trials?
Pretty sure you know the answer to your own question.
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