Posted on 04/11/2024 9:13:05 PM PDT by ConservativeMind
Researchers have found a mechanism responsible for increasing the risk of developing cancer among patients with heart disease: Small extracellular bubbles, or vesicles (sEVs), secreted from the sick heart to heal itself, are released into the bloodstream and promote the growth of cancer cells throughout the body.
"Our research revealed that the diseased heart secretes cancer-promoting factors, which we identified as small extracellular vesicles (EVs). These are tiny particles wrapped in a simple membrane, which all cells secrete, but because of heart damage, these vesicles are released in greater quantities and contain factors related to inflammation, healing, growth, creation of new blood vessels, and changes in the immune system.
"These vesicles move through the circulatory system and eventually reach the tumor or the pre-cancerous tissue," Caller adds. "Following an injury in the heart muscle and deterioration to heart failure, sEVs containing growth factors and small nucleic acid molecules that promote cell division are released. These sEVs contribute to the healing of the injured cardiac tissue. However, released from the injured heart, those vesicles move within the body's circulatory system, eventually targeting cancerous growths."
Prof. Leor says, "When you systemically inhibit the formation of sEVs, you get less cancer—but you cause collateral damage along the way. That is why we tried a different strategy: Treat the patient's heart to reduce the damage to the cardiac tissue so that it secretes fewer sEVs."
"We used spironolactone, which is a well-known, old and effective drug used to treat heart failure. We treated the animals with spironolactone at a very early stage of the disease and found that the heart secreted 30% fewer sEVs—and the cancerous tumors grew more slowly. Our experiment shows that it is possible to intervene in heart disease in a way that reduces the risk of cancer among heart patients."
(Excerpt) Read more at medicalxpress.com ...
This may be a better option than newer drugs, when cancer may concurrently exist.
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Isn’t that one of the drugs that trans people use to suppress testosterone?
Yes, but with a heart attack, there should be a period of time of its own injury repair when this would be helpful, and it could be stopped later.
Wikipedia:
https://en.m.wikipedia.org/wiki/Spironolactone
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