Stopping aspirin 1 month after coronary stenting significantly reduces bleeding complications in heart attack patients (by 55%)

Medical Xpress / The Mount Sinai Hospital / The Lancet ^ | April 7, 2024 | Zhen Ge et al

[ConservativeMind]

Withdrawing aspirin one month after percutaneous coronary intervention (PCI) in high-risk heart patients and keeping them on ticagrelor alone safely improves outcomes and reduces major bleeding by more than half when compared to patients taking aspirin and ticagrelor combined (also known as dual antiplatelet therapy or DAPT), which is the current standard of care.

These are the results from the ULTIMATE-DAPT study.

The study analyzed 3,400 patients with ACS at 58 centers in four countries between August 2019 and October 2022. All of the patients had undergone PCI, a non-surgical procedure in which interventional cardiologists use a catheter to place stents in the blocked coronary arteries to restore blood flow. The patients were stable one month after PCI and were on ticagrelor and aspirin. Researchers randomized the patients after one month, withdrawing aspirin in 1,700 patients and putting them on ticagrelor and a placebo, while leaving the other 1,700 patients on ticagrelor and aspirin. All patients were evaluated between 1 and 12 months after the procedure.

During the study period, 35 patients in the ticagrelor-placebo group had a major or minor bleeding event, compared to 78 patients in the ticagrelor-aspirin group, meaning that the incidence of overall bleeding incidents was reduced by 55 percent by withdrawing aspirin. The study also analyzed major adverse cardiac and cerebrovascular events including death, heart attack, stroke, bypass graft surgery, or repeat PCI. These events occurred in 61 patients in the ticagrelor-placebo group compared to 63 patients in the ticagrelor-aspirin group, and were not statistically significant—further demonstrating that removing aspirin did no harm and improved outcomes.

[ConservativeMind]

It seems aspirin complicate health if continued beyond the one month point.

Give this study write up to your doctor, if this is a concern with your circumstance.

[ConservativeMind]

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[Romulus]

Anyone out there taking generic Brilinta?

[higgmeister]

Stopping aspirin 1 month after coronary stenting significantly reduces bleeding complications in heart attack patients (by 55%)

That sounds like a "well, duh" moment there.