If you are taking a drug that is metabolized by one or more P450 enzymes to be effective AND you are taking a weak inhibitor AND you already have genetic problems...then YES...you should be aware of the issue..because a weak inhibitor now has the potential to have a strong effect.
This is one of the points that study on HCQ was making about patients in the hospital with COVID. I think they mentioned QUercetin in that study but it has been awhile since I read it.
And btw, the Flockhart table is pretty stringent on when they will change the drugs on that list. So when Covid first started HCQ wasn’t even listed but now it is listed as a weak inhibitor. In reality..it is a substrate...but they need more studies before they will change it.
The drug hasn’t changed during those years. Doctors were clueless..and likely still are about HCQ and P450. It will take more studies before Flockhart table will change and meanwhile patients like me have to figure out how to navigate Drugs that could be clearly problematic.
I have one Doctor that said don’t take it for my auto immune issues. Safer not to take it. I agree. Of course, I haven’t had Covid.