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To: grey_whiskers
Notice how that company didn't rush pell-mell into manufactured RNA jobs (specifically engineered to resist degradation by the body) masquerading as vaccines.

Ah, I see that you do not have a background in nucleic acid chemistry. Lucky for you, half of my PhD was based on learning all of the basics about nucleic acid chemistry. This field of science is called "molecular biology."

Now, I do not know the term "manufactured RNA jobs" and it actually does not make much sense. Are those jobs where people are employed to make RNA in a laboratory? Anyways...

The purpose of the modified RNA is to bypass the innate immune response against foreign RNA. Foreign RNA is typically the RNA contained in food or in microorganisms in your body. In addition to the innate immune response which just destroys the RNA, RNA can provoke an adaptive immune response, meaning that it provokes the formation of T-cells, B-cells, and antibodies against the RNA. Since the purpose of a vaccine is to cause an adaptive response to proteins, the adaptive immunity raised against RNA is problematic for a couple of reasons. An unmodified mRNA vaccine formulation might not survive long enough to reach the lymph nodes where the adaptive immune response takes place. And immunity against a viral mRNA is useless, since all viruses package their mRNA inside a protein-studded lipid membrane, where the immune system can't see it.

The specific modification of the RNA is to add a methyl group to the uracil, making 1-methylpseudo UTP. (UTP=uracil triphosphate) With this modification, the immune system no longer recognizes the foreign RNA. However, all of the RNA metabolism enzymes recognize it just like unmodified RNA. This means that the RNA polymerases that make the mRNA are perfectly capable of making the 1-methylpseudo UTP modified RNA. And the RNAse enzymes that chew RNA into its component nucleotides work equally well to chew up the 1-methylpseudo UTP modified RNA.

So, when you get your modified mRNA Covid-19 shot, the particles containing the mRNA enter the lymph nodes closest to the injection site. Cells in the lymph nodes internalize the particles by fusing with the lipid membrane and releasing the mRNA into the cytosol. Once there, the mRNA attaches to ribosomes where it directs the formation of modified spike protein. Since the spike protein is a membrane bound protein, it is inserted into the cell membrane so that the cell ends up having spike protein on its surface. (This also happens during viral infection.) Once the protein synthesis is complete, the ribosome releases the mRNA, which is then destroyed by RNAses inside the cell. mRNA within a cell typically has a half-life of less than a day; sometimes the half-life is just minutes, depending on the specific mRNA molecule.

Any of the following papers describing mRNA vaccine development prior to the pandemic will give you more details on the rationale of mRNA modification:

Modified mRNA Vaccines Protect against Zika Virus Infection.

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease.

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques.

77 posted on 10/27/2023 6:06:32 AM PDT by exDemMom (Dr. exDemMom, infectious disease and vaccines research specialist.)
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To: exDemMom

The m in mRNA in the jabs is not messenger but modified.

Fir jobs substitute jabs.

Stupid autocorrect.

The rest of your post went into /dev/null because it’s coming from a known troll.


78 posted on 10/27/2023 6:46:38 AM PDT by grey_whiskers ( The opinions are solely those of the author and are subject to change without notice.)
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To: exDemMom
Since the purpose of a vaccine is to cause an adaptive response to proteins, the adaptive immunity raised against RNA is problematic for a couple of reasons. An unmodified mRNA vaccine formulation might not survive long enough to reach the lymph nodes where the adaptive immune response takes place. And immunity against a viral mRNA is useless, since all viruses package their mRNA inside a protein-studded lipid membrane, where the immune system can't see it.

So you're talking in circles.p> Because the jabs were never designed to provoke an adaptive immune response to the m(modified)RNA, but to a specific protein generated by the m(odified)RNA.

The real problem was the innate response;and how to get the genetic package into the cells, *and* to have it last long enough to do it's dirty work of hijacking the protein construction to crank out artificial (therefore fixed, therefore losing efficacy in provoking immune response as the natural spike mutates in the wild over time).

So why you're wasting your time trying to bluster at people with a non-sequitur straw man is anyone's guess.

Maybe you're just paid by the word.

79 posted on 10/27/2023 6:59:42 AM PDT by grey_whiskers ( The opinions are solely those of the author and are subject to change without notice.)
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