Posted on 02/16/2023 8:26:58 PM PST by ConservativeMind
High-dose oral vitamin D reduced skin inflammation and increased immunoprotection in patients with chemical-induced skin rashes, according to findings from a recent clinical trial.
The investigators, led by Kurt Lu, MD, also discovered in these patients a new molecular signature that may help physicians identify which patients have an increased risk of developing severe allergic reactions to treatments including topical chemotherapy.
"Oral vitamin D is a safe and readily available over-the-counter nutritional supplement with anti-inflammatory and immunoprotective properties, while boasting no adverse effects," Lu said. "This study also provides a new avenue of exploration for druggable targets to both reduce consequences of injury and enhance wound healing," Lu said.
In the randomized, double-blinded clinical trial, investigators analyzed skin tissue samples from 28 healthy participants whose inner arm skin was exposed to a test amount of topical nitrogen mustard, an FDA-approved medication with known chemical irritant properties, to produce an experimental rash. Participants then received either a high-dose oral vitamin D intervention or placebo.
Overall, skin tissue in participants that received vitamin D supplements demonstrated less irritation and inflammation than the placebo group.
Subsequent multi-omic analyses of skin tissue and blood samples from the vitamin D group also revealed suppression of the pro-inflammatory IL-17 signaling pathway.
This establishes IL-17 signaling as a promising biomarker, which is important because severe reactions to topical chemotherapy and other medications can either delay or prevent patients from receiving adequate treatment, according to Lu.
"Our molecular signature may help identify patients at-risk for developing a severe allergic response, allowing clinicians to make early adjustments to the treatment regimen or implement supportive therapies. We suggest that giving patients vitamin D when they begin medical treatment may suppress these severe reactions," Lu said.
(Excerpt) Read more at medicalxpress.com ...
I had some skin issues, and a lack of tanning.
Obviously I believe the evidence shows natural vitamin D has to be far better than artificial pill supplements.
Unfortunately I was unable to find enough peer reviewed studies to prove this and my doctor refused to give me a BMW m3 prescription
I probably should have found more supporting data?
“Oral vitamin D is a safe and readily available over-the-counter nutritional supplement with anti-inflammatory and immunoprotective properties, while boasting no adverse effects,”
It is possible to overdo Vitamin D. An autoimmune disease was reducing my D level to zero so I was being given 50,000 units a week. Not a problem while the disease was active.
When the disease went into remission the docs told me to take D supplements on my own but they didn’t specify how much. Sometimes I’d take 2,000 units a day, sometimes 5,000.
I’d been taking 5,000 a day before my last blood panel and when the doc got the report she said “What the hell are you doing? Your Vitamin D and Calcium levels are off the chart!” An excessively high level of D causes your blood calcium level to get too high and that can damage your bones and your kidneys. So if you are going to take high doses of D you’d be wise to get your levels tested.
With respect to excess calcium brought about by taking vitamin D3, my suggestion is to search YouTube and the Internet for information about taking vitamin K-2 MK-7 along with your vitamin D3. Some argue that the K-2 MK-7 helps move the excess calcium to your bones. Review what you find with your doctor as I did with mine. I am no MD and have never worked in the medical field, but your doctor should be able to evaluate what you find.
You might also watch Dr John Campbell on YouTube. He is a British PhD Nurse who has trained nurses. Here is a link to one of his daily YouTube videos about Vitamin D3 and read the comments people make about each of his videos:
https://www.youtube.com/watch?v=x5sc7G4s4CY&t=19s
Bkmk
It is called Hypercalcemia and actually leaches calcium out of your bones and deposits it into your bloodstream. I found out the hard way as you apparently did. It is the same material found in rat/mice poison and is the mechanism of their death. My symptom was whole bone pain, a finger bone on my left hand and my right thigh bone. I thought what the hell is going on. The 50,000 unit “hammer” is more destructive than some doctors realize. My personal limit is 4,000 units without ill effects.
Great news.
If you can take it without reacting......
.
Take Vitamin K along with the D3 and K2 together - that regulates the calcium where it should be going (to your bones) instead of where you don't want it (in your arteries and other unwanteds).
Here's a good book on the subject:
“It is called Hypercalcemia and actually leaches calcium out of your bones and deposits it into your bloodstream. I found out the hard way as you apparently did.”
Yep. I didn’t know Vitamin D toxicity even existed until my nephrologist started yelling at me. Fortunately I get big blood panels a couple of times a year so it was caught before any real damage was done. I hope you managed to come out okay.
Perhaps try the Z4.
Full fat yogurt. Eggs. Fermented cheese. Sauerkraut. These are sources of K2 that are routine in my diet. The K2 level shouldn’t be a problem. But the daily 5,000 D supplement was raising my blood calcium above the safe range.
I pretty much stick with just one 1,000 unit jel-cap a day now. There is a youtube video of a doctor actually pointing out it is the main component in rat poison. My “doctor” had given me a 2 week supply of 50,000 unit pills. Was someone trying to kill me or just a dumb ass?
Actually, it’s not easy to get the full daily K2 needed for deficient elderly.
Pastured eggs have lots, the most of anything else other than natto (the best, but stinky and hard to find here). Also there are different forms of K2. Two seem to be very important.
You can look it up online. No, not the stupid “health sites” but the nitty gritty nutrition sites.
There are supplements of course. Again be careful which form and amount of K2 you actually get.
Not arguing. Just contributing.
For the K2, I take a 100mgc K2 along with a 10,000 D gelcap. No problems - I think the ratio is good.
Probably just dumb. But 50,000 units a day would certainly not be a good idea.
Tokyo Central Market is a short drive from me if I want to try natto. But soybeans and I don’t agree so I’ll pass on that idea.
If I get nicked shaving I don’t bleed for long so my K2 can’t be too low. I could see if my neph wants to add K2 to the blood panel, she tests for everything under the sun anyway. But I don’t know if she would want my K2 levels to be high, I’m prone to “venous and arterial thrombosis” thanks to the same syndrome that makes me lose all of my D3 at times. That’s not K2 related, it’s from a loss of anticoagulant clotting factors.
It’s K1, not K2, that helps control blood clotting properly. When we are young, our bodies easily convert K1 to K2, and K1 is pretty abundant in our diet, even present in lettuce. As we age, our bodies are not so good at converting K1 to K2. K2 is like a “boss” directing calcium in the blood. It says “go into the bones”. Without the K2 “boss”, calcium accumulates inside our blood vessels, which is not exactly fun. We get clogged arteries and osteoporosis :(
Ref your “soybeans and I don’t agree” — well, I guess you’re not a cow, lol. Soybeans are cow food. At least in my my book they are.
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