Hit a big cat with a .22 CB, it won't even feel it. As an old soldier once said: "You shoot me with that toy, and I find out......
I was posting about the coyote problem in an area infested with Karens. Those are (supposedly) frangible rounds. Pest gets shot and goes somewhere to die.
Place a CB cap into the heart lungs it will wander off and die soon.
Place it in the liver it will wander off and die in a week or so.
Shot placement is king.