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Type 2 diabetes remission is possible even in people with lower body weight, supporting idea of 'personal fat threshold'
Medical Xpress / Diabetologia / European Association for the Study of Diabetes (EASD) ^ | Sept. 22, 2022 | Professor Roy Taylor et al

Posted on 09/24/2022 1:02:19 PM PDT by ConservativeMind

Everyone has a "personal fat threshold," which if exceeded, will allow type 2 diabetes (T2D) to develop, even if they are of a lower body weight.

The ReTUNE Study looked at whether weight loss can also reverse the condition in people with a BMI at or only just above the "normal" range (BMI below 27kg/m2).

Men and women with T2D followed a weight loss program in which they consumed 800 calories a day for two weeks, followed by four to six weeks in which they kept their new weight steady. They completed up to three rounds, until they had lost 10–15% of their body weight.

70% with type 2 diabetes went into remission. Remission is an HbA1c (average blood sugar level) of less than 48mmol/mol for at least 6 months and off all medication. Participants had lost an average of 7.7kg at remission (10.7% of initial weight).

Special MRI scans showed that levels of fat inside the liver and pancreas fell substantially. Even though the average amount of fat in the liver of the study participants would be regarded as unremarkable at 4.1%, this was around three times higher than in healthy controls and it fell to 1.4%. Fat in the pancreas fell from an average of 5.8% to 4.3% and the activity of the insulin-producing cells returned towards normal.

The researchers say that their results clearly demonstrate that T2D is caused by the same factors in normal weight people. This is important because doctors tend to assume that T2D has a different cause in those with lower body weights and aren't usually advised to lose weight before starting on diabetes drugs.

"But if they lost around 10% of their weight, they would have a very good chance of putting their type 2 diabetes into remission," says Professor Roy Taylor.

(Excerpt) Read more at medicalxpress.com ...


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Virtually all Type 2 diabetics are capable of having their diabetes go i to remission.

This is great news! No more progression of health issues is necessary!

1 posted on 09/24/2022 1:02:19 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20% fewer pings) or “Everything” list.

2 posted on 09/24/2022 1:03:05 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

The government spends a lot of money assisting the medical professions and drug companies, for development of treatments and drugs to combat diabetes.

But, if lowering weight is a better method for beating diabetes, then, that money should be going towards incentives to get people to lower and keep their weight down. That would be a lot cheaper than having to pay for medical care, especially for the older folks with diabetes.


3 posted on 09/24/2022 1:19:09 PM PDT by adorno
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Comment #4 Removed by Moderator

To: ConservativeMind

Type2 is primarily due to processed foods. Avoid. Simple.


5 posted on 09/24/2022 1:20:08 PM PDT by Chauncey Gardiner
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To: adorno

This may sound extreme but I believe that if we all could maintain our high school bodyweight a lot of medical problems would be solved or not even exist. I know that’s a ridiculous tall order but think back to your high school weight. And it might just take you to that area where the study is recommending that you go. I have another eight more pounds to reach my high school graduating weight which was 132 lbs. I’m at 140 lbs right now. I started my journey at 168 pounds at 5 foot six inches.


6 posted on 09/24/2022 1:27:33 PM PDT by magua (It's not racism, it's just that thisBecause it’s being reported that a lot of this started in 2015.)
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To: mass55th

It sounds like you are speaking on behalf of those who have no courage, which is well-mentioned in your tagline/signature.

I am glad they have someone to represent them, such as yourself.


7 posted on 09/24/2022 1:32:20 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: magua

I’m trying to get back to my Marine Corps weight of about 155 lbs. I’ve got 12 more to go.

My doctor says that I have the pulse of a healthy 24 year old, but, I’m 77. I don’t feel like 24, but, my pre-diabetis diagnosis is gone.


8 posted on 09/24/2022 1:34:46 PM PDT by adorno
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To: adorno

“healthy 24 year old“
Doesn’t that sound nice. I often believe in low tech solutions for nasty little problems. And what could be more low tech then stopping eating beyond a certain point. Good luck with those last 12 pounds Junior.


10 posted on 09/24/2022 1:47:31 PM PDT by magua (It's not racism, it's just that thisBecause it’s being reported that a lot of this started in 2015.)
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To: ConservativeMind

Diet and exercise is how to solve the problem of being fat.


11 posted on 09/24/2022 2:00:19 PM PDT by jdt1138 (Where ever you go, there you are.)
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To: ConservativeMind

A mere 800 calories A DAY????!!!!

The shock alone might kill some people.


12 posted on 09/24/2022 2:16:54 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ConservativeMind

If I can have ice cream and cookies and chicken wings and potato chips and hot fudge sundaes, I’m all for it.


13 posted on 09/24/2022 2:18:52 PM PDT by Lazamataz (The firearms I own today, are the firearms I will die with. How I die will be up to them.)
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To: adorno

I have the body of a 21 year old athelete.

I hope the police don’t find out.


14 posted on 09/24/2022 2:20:12 PM PDT by Lazamataz (The firearms I own today, are the firearms I will die with. How I die will be up to them.)
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To: LambSlave

Who the hell weighs 90 pounds? And effing midget? I’ve seen enough people on their deathbed weighing that. 5’7 and 160 and still pre diabetic. What did I get from working out all the time and eating better? Vertigo and fainting spells. I felt better when I was fatter. Im finding a diet that gives me a quick heart attack so I can check out quicker without any long goodbyes.


15 posted on 09/24/2022 2:32:42 PM PDT by dragonblustar (Romans 12:12)
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To: dragonblustar; mass55th; Lazamataz
Folks, apparently you just need to lose 10-15% of your body weight. If you are 200 pounds, at most, that means getting to 170, or losing 30 pounds.

I'd suggest then eating a lower carb-type of diet, but eating to maintain your new weight should keep your blood sugars okay. This doesn't fully reverse the damage of diabetes, but it does mean you won't have more degeneration and you won't need drugs, if done right.

You still have diabetes, but it's no longer capable of affecting you, if you stay balanced in the new approach (don't eat 2,000 calories of sweets a day for your meals, all at once).

There are some study examples of intermittent fasting and keto that bring people near 600-800 calories a day (called pseudo-fasting) for five days out of something like each 40 days, and this was found to migrate stem cells into the pancreas and rebuild beta cells, so it may be possible to fully reverse diabetes, over time.

16 posted on 09/24/2022 2:50:44 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I am so screwed.


17 posted on 09/24/2022 2:51:20 PM PDT by Lazamataz (The firearms I own today, are the firearms I will die with. How I die will be up to them.)
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To: ConservativeMind

I ws on Metfromin for a lot of years but after my doctor took me off it, my A1C still runs around 6.0. She now calls me a diet controlled diabetic. If I gourge out on carbs I can bet my blood sugar shoots up.


18 posted on 09/24/2022 2:59:46 PM PDT by antidemoncrat (.)
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To: adorno

“...especially for the older folks with diabetes.”

That’s a misnomer. Diabetes II is not always caused by weight consideration. Many people are getting it while in good shape. I was determined to have it when I was in the best shape of my life. I was active duty military, ran over 5 miles a day, had a 42” vertical leap, and could squat 500 lbs. three times in a set at 185 pounds and 6 ft 2 inches. But I was also not near retirement age.

But the idea that losing weight is the way to get rid of the illness for older people is not workable. In the first place the magic of losing weight is the use of exercise. Diets that reduce intake are a problem for diabetics. Being able to burn off calories equal to your intake, especially a little more with insulin resistance, is beyond many seniors capabilities so doing it by intake only will cause many things for the body to do to you. It makes it very easy for the body to go hypo and get down to dangerous levels. I’ve done that and passed out at 24 once.

And by having insulin resistance, the body is going to capture a certain amount of storage to go to the midriff and there is no way to guess how much that is going to be.

Exercise is a major component of diet. A good article on this is by webmd:

https://www.webmd.com/diabetes/diabetes-diet-exercise

Old people can’t exercise well.

wy69


19 posted on 09/24/2022 3:08:56 PM PDT by whitney69
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To: magua
And what could be more low tech then stopping eating beyond a certain point.

Stopping eating isn't a problem for me. I lose weight by dieting, and exercising isn't in my plans. I should exercise, but, I'm too lazy for that.

I actually used to weigh 208 some time ago, and I lost some 45 lbs by eating less, in about 4 months. I've kept most of those pounds off in the last 20 years, and if I gain, it's perhaps 5-10 lbs a year. But, losing weight is not a problem for me, and I can lose 5-10 lbs per month easily. I may get to my military weight in another month, but, I'm not in desperation mode, and losing 1 pound per week is my goal.
20 posted on 09/24/2022 3:27:18 PM PDT by adorno
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