Two new treatments for Crohn's disease equally effective (Adalimumab or Ustekinumab = 61-65% full remission)

Medical Xpress / Northwestern University / The Lancet ^ | July 18, 2022 | Will Doss / Bruce E Sands et al

[ConservativeMind]

If I had to take one of these, I would personally prefer Adalimumab, as tumor necrosis factor (TNF) alpha influences all sorts of other often oit-of-control inflammatory processes. Interestingly, many antioxidants reduce TNF to achieve their benefit. Diet and exercise can help with this, too.

As always, talk with your doctor about what is best for you.

[ConservativeMind]

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[z3n]

“...I would personally prefer Adalimumab...”

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take B12 and L-Glutamine, and call me in 2 weeks

[Red Badger]

I know people with this!...................

[butlerweave]

My brother is having surgery right now one of many because of an infection , he’s been fighting Crohn’s since 1995

[PMAS]

**

[JubJub]

Bookmark

[AppyPappy]

My son’s best friend. He uses cannabis for it.

Wrester and teacher/coach George The Animal Steele (Jim Myers)

[MIchaelTArchangel]

When I was in school (yes, more than half a century ago), no one outside the medical community had ever heard of Chron’s Disease. If someone mentions spastic a-holes, we thought they were talking about nurds in a gym class.

[MIchaelTArchangel]

When I was in school (yes, more than half a century ago), no one outside the medical community had ever heard of Crohn’s Disease. If someone mentions spastic a-holes, we thought they were talking about nurds in a gym class.

[nagant]

If I had to take one of these, I would personally prefer Adalimumab, as tumor necrosis factor (TNF) alpha influences all sorts of other often oit-of-control inflammatory processes. Interestingly, many antioxidants reduce TNF to achieve their benefit. Diet and exercise can help with this, too.
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I second your assessment. TNF alpha is at the headwaters of cytokines. Look at the cytokine response lists of so many inflammatory diseases and you find TNF alpha most of the time.

[aquila48]

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[Bob434]

The older drugs like 6-mp and some others had some pretty nasty side effect. They were designed to control tnf as well if I recall correctly. I know folks that kept getting boils and sores, and lung problems while on the drugs. And when flues came around had to be extra careful not to get them if they caused lung issues.

Hopefully the news meds are a bit gentler.

[Bob434]

I wonder if controlling tnf would be a way to defeat covid for those most at risk? Crohns and related diseases are where the body turns on itself and attacks it, destroying systems like digestive system, and covid I think is where the body turns on itself too? (Causing cytokin storms)?

[Bob434]

I wish him well, it’s an awful disease-

[ChinaGotTheGoodsOnClinton]

I wonder how much of this explosion in diagnosed cases is due to poor gut biomes due to the lack of fermented foods in the standard western diet.

[NewHampshireDuo]

ping

[cyclotic]

My son has it. He got it at 17. Did a few years of a genetic infusion treatment then decided to have a few inches of intestine removed.

He’s in total remission since.

[dkGba]

That’s wonderful Glad to hear that

[usconservative]

It's been known for some time now that Adamibulab (Humira) is effective against Crohn's. I'd read about it at least 10 years ago and passed it onto a friend who's wife has Crohn's.

She's been on Humira for it for about 8 years for it. I take Humira to manage my Ankylosing Spondylitis. It's been a life-changing drug for me.