AcuteMyeloidLeukemia #AML #Ivermectin
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in (AML) leukemia cells
In summary, we have shown that ivermectin induces cell death in leukemia cells via chloride influx, membrane hyperpolarization, and increasing levels of intracellular ROS. Given its prior safety record in humans and animals coupled with its preclinical efficacy in leukemia, a phase 1 clinical trial could be conducted to determine the tolerance and biologic activity of oral ivermectin in these patients.
The online version of this article contains a data supplement.
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