Scientists mystified, wary, as Africa avoids COVID disaster

AP ^ | 11/18/2021 | MARIA CHENG and FARAI MUTSAKA

[simpson96]

HARARE, Zimbabwe (AP) — At a busy market in a poor township outside Harare this week, Nyasha Ndou kept his mask in his pocket, as hundreds of other people, mostly unmasked, jostled to buy and sell fruit and vegetables displayed on wooden tables and plastic sheets. As in much of Zimbabwe, here the coronavirus is quickly being relegated to the past, as political rallies, concerts and home gatherings have returned.

“COVID-19 is gone, when did you last hear of anyone who has died of COVID-19?” Ndou said. “The mask is to protect my pocket,” he said. “The police demand bribes so I lose money if I don’t move around with a mask.”

[A strike]

“The thing is - if Ivermectin works so well - why are no nations actually prescribing it. “

Are you even halfwit serious ??!!!

[DOC44]

“Drug used for Malaria!”

and they have worm and skin parasites which ivermectin is also used to kill.

[Pelham]

Which nations are prescribing it?

[LilFarmer]

Here are the countries it is in use for covid:

https://ivmstatus.com/

[LilFarmer]

Here are the countries it is in use for covid:

https://ivmstatus.com/

[Karl Spooner]

Short-course ivermectin is widely used to treat worm infections, and its beneficial properties for this purpose are well known. It is not used for prevention, unlike chloroquine, a close relative of HCQ, which is consumed daily by millions.

No, Ivermectin is used for all phases of Covid 19 including prevention for Covid 19. You must not be keeping up and are basing your opinion on antiquated information. Ivermectin uses are evolving.

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"Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin.

Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified."

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8088823/

[Jim Noble]

No, Ivermectin is used for all phases of Covid 19 including prevention for Covid 19. You must not be keeping up and are basing your opinion on antiquated information

My statement was that ivermectin is not commonly used as a preventative in Africa, certainly not enough to account for the favorable experience of hundreds of millions of black people in a tropical climate.

I stand by it.

[MayflowerMadam]

Isn’t that why Ivermectin was invented — for India and Africa because of the parasite issues?

[Pelham]

Thanks.

The most recent date on these reports appears to be January 2021, which would put most of them before any vaccines were available. And certainly before monoclonal antibody therapy. Mid December 2020 was when the first vaccines were available and for awhile that was limited to the UK and the US.

This was a period when anything that might work was being tried. I’d be curious to know how many are still using IVM.

[RetiredTexasVet]

Any fool could, but our CDC, NIH, FDA, etc are completely baffled, but then again none of those agencies are staffed by doctors or scientists ... just corrupted political weenies.

[Jim Noble]

“Isn’t that why Ivermectin was invented — for India and Africa because of the parasite issues?”

Yes. Ivermectin has broad anti-helminth activity but it was pushed forward specifically to treat and prevent onchocerciasis (River Blindness) in West Africa.

At a very early stage of my career I wanted to join the Army to do River Blindness work in Africa, but fate, as they say, took a hand and I wound up in Boston instead.

I read a great, but very long, paper last night that attempted a meta-analysis of every published ivermectin COVID trial, which seemed to show that the strongest “signal” for effectiveness was in countries with high worm burdens, as if the worms are a cofactor that makes COVID more severe or more likely to be fatal.

[A strike]

“Which nations are prescribing it?”

How about Results from Uttar Predesh India, most of Africa, now allowed in Japan, the Phillipines, Brasil and a number of others where the Pharma BILLIONS in profits have yet to crush HCQ and Ivermectin ?

Pretty damn weird that all the “first world” countries with the highest rates of (not)vaccine forced compliance have the highest coronavirus cases and DEATH.
How in the hell can that be ?!

[Pelham]

https://www.isglobal.org/en/healthisglobal/-/custom-blog-portlet/ivermectina-del-suelo-a-las-lombrices-y-mas-alla/3098670/0

Ivermectin: From Soil to Worms, and Beyond
21.11.2019

The incredible story of the drug’s discovery, impact and possible future uses.

What do penicillin, aspirin and ivermectin have in common? Apart from the fact that they rhyme, all three belong to a very select group of drugs that can claim to have had the “greatest beneficial impact on the health and well-being of humanity”.

They have at least two other things in common: all three were found in nature and all three led to a Nobel prize. Aspirin is derived from salicin, a compound found in a variety of plants such as willow trees. Its use was first mentioned by Hippocrates in 400 BC, but was isolated only in 1829 as salicylic acid and synthesised some years later as acetylsalicylic acid. The discovery of the mechanisms underlying aspirin’s effects gave Sir John Vane the Nobel prize in 1982. Penicillin was isolated from mold that grew by accident on a Petri dish in Alexander Fleming’s laboratory. Its discovery changed the course of medicine, and earned Fleming the Nobel prize in 1945, which he shared with Howard Florey and Ernst Chain.

And this brings us to ivermectin- not likely a drug you will have in your first-aid kit, like aspirin or penicillin, but definitely a drug that has improved the lives of millions of people since its discovery in 1975.

The long journey of a Japanese soil sample

The story of how ivermectin was discovered is quite incredible. In the late 1960s, Satoshi Ōmura, a microbiologist at Tokyo’s Kitasako Institute, was hunting for new antibacterial compounds and started to collect thousands of soil samples from around Japan. He cultured bacteria from the samples, screened the cultures for medicinal potential, and sent them 10,000 km away to Merck Research Labs in New Jersey, where his collaborator, William Campbell, tested their effect against parasitic worms affecting livestock and other animals. One culture, derived from a soil sample collected near a golf course southwest of Tokyo, was remarkably effective against worms. The bacterium in the culture was a new species, and was baptised Streptomyces avermictilis. The active component, named avermectin, was chemically modified to increase its activity and its safety. The new compound, called ivermectin, was commercialised as a product for animal health in 1981 and soon became a top-selling veterinary drug in the world. Remarkably, despite decades of searching, S. avermictilis remains the only source of avermectin ever found.

Remarkably, despite decades of searching, S. avermictilis remains the only source of avermectin ever found.

Campbell urged his colleagues to study ivermectin as a potential treatment for onchocerciasis (also known as river blindness), a devastating disease caused by worms and transmitted by flies, that left millions of people blind, mostly in sub-Saharan Africa. The first clinical trials in Senegal showed that the treatment worked, and ivermectin was approved for human use in 1987. Since then, more than 3.7 billion doses (donated by Merck laboratories) have been distributed globally in mass drug administration campaigns against onchocerciasis and lymphatic filariasis (another disease caused by worms, which causes severe swelling of limbs). The impact of ivermectin in decreasing the burden of these devastating diseases is immeasurable. Deservedly, Ōmura and Campbell won the Nobel prize for physiology and medicine in 2015 “for their discoveries concerning a novel therapy against infections caused by roundworm parasites” (they shared it with Youyou Tu, who discovered the antimalarial drug artemisinin). But ivermectin’s story of success does not end here.

A game-changing drug with many potential uses

Ivermectin, in fact, was the world’s first “endectocide” – a drug with activity against a wide variety of internal and external parasites, from nematodes to arthropods. It has also proved to be astonishingly safe for humans. This is because the drug acts by binding to special channels on the cell membrane (called glutamate-gated ion channels) that play a fundamental role in nematodes and insects. In mammals, however, the drug has no effect since the neurons expressing these channels are protected by the blood brain barrier. In addition to its high safety profile, no convincing evidence of drug resistance has been found to date among Onchocerca worms, despite 30 years of continued use and billions of doses administered.

All this explains why ivermectin is becoming increasingly attractive to treat other diseases in humans. For example, long-term treatment with ivermectin to control onchocerciasis was shown to reduce the prevalence of other parasitic worms called soil-transmitted helminths, which infect up to one fifth of the world’s population and are a major cause of malnutrition and growth impairment in children. Furthermore, ivermectin is very effective against Strongyloides, a roundworm that infects up to 35 million people every year. This has motivated studies - such as the STOP project led by ISGlobal - to test the efficacy of adding ivermectin to the current recommended treatment against these intestinal worms.

Ivermectin has also proved to be effective against external parasites such as head lice and the tiny Sarcoptes mite, which causes scabies (an itchy skin condition, of which there are 3oo million cases every year).

But that is not all. The observation that mosquitoes feeding on individuals treated with ivermectin have a shorter lifespan, inspired the innovative idea of using the drug as a “weapon” against malaria-transmitting mosquitoes. The BOHEMIA project, also led by ISGlobal, will test the impact of giving ivermectin to entire communities, and their livestock, on mosquito populations and malaria prevalence in two highly endemic areas for the disease.

The BOHEMIA project, also led by ISGlobal, will test the impact of giving ivermectin to entire communities, and their livestock, on mosquito populations and malaria prevalence in two highly endemic areas for the disease.

Because of its impact, safety and versatility, ivermectin has earned the title of “wonder drug” among public health specialists. Treating entire communities with the drug could represent a safe and effective means of “hitting several birds with one stone”; in other words, reducing the prevalence of several disabling parasitic diseases and improving overall community health in the developing world. Whether ivermectin lives up to these great expectations, remains to be seen. Meanwhile, its trip from a Japanese sample soil to improving the lives of millions of people affected by parasitic worms, is definitely worth a story.

Stay informed on the COVID-19 scientific updates and other global health issues. Click here to sign up for email updates from ISGlobal.

[Jane Long]

Never hurts to remind folks of the history of Ivm.

It’s been posted numerous times, here on FR, but always good for those who may not know/have been under a rock, to read up on.

[just me]

No 24/ 7 media propaganda?

[Karl Spooner]

I stand by it.

You must live in a cave or something. Do you know the meaning of the word prophylaxis ?

=====================================================

"Many regions around the world now recognize that ivermectin is a powerful prophylaxis and treatment for COVID-19. South Africa, Zimbabwe, Slovakia, Czech Republic, Mexico, and now, India, have approved the drug for use by medical professionals. The results as seen in this latest study demonstrate that the ivermectin distribution campaigns repeatedly led to “rapid population-wide decreases in morbidity and mortality.”

http://outbreaknewstoday.com/ivermectin-is-highly-effective-as-a-safe-prophylaxis-and-treatment-for-covid-19-comprehensive-review-12291/

=====================================================================

[The Duke]

Actually, a good way to tell if it is Ivermectin or climate is to look at the nation of Panama. Panama has almost completely eradicated malaria (thank you Teddy Roosevelt!), but is surrounded by other countries where it is still a big problem.

[Texas Fossil]

AP = Always Propaganda

[Jim Noble]

“Do you live in a cave”

No.

What I said was, ivermectin is not widely used IN AFRICA for prevention of COVID. And it isn’t.

[Karl Spooner]