So let's remember, first, that no Founder ever proposed or supported unapproved Declaration of Secession at pleasure, but all did support "secession":
Then Congress decided that not only must the Confederate army be defeated, but also slavery must be abolished.
And in due time the Supreme Court decided that, legally, the Confederacy never existed except as a pretend fiction among rebels.
Today, a constitutional convention of the states could, if ratified, authorise some States to withdraw and add other new States, legally, no need for separate declarations or threats of war.
Seems unlikely, but not impossible.
You could not get a constitutional convention today to agree on the Lord's Prayer.
Your preferences - and the Supreme Court justices vote to pass the law Texas v White - drained the Declaration of Independence and the U.S. Constitution of any real meaning.
There is no need to leave your place to get medicated. Peek out your window: that MRAP in your drive has more than enough stuff to medicate your entire family. The federal government is coming to help you.
Jeffersondem is persistent if nothing else: after the disaster at Appomattox, we ceased to have a government based on consent of the governed and lapsed into a government based on a supermajority of bayonets.