A GUIDE TO THE MANAGEMENT OF COVID19. Pre and Postexposure Prophylaxis (The I-MASK+ protocol) The components of the I-MASK Prophylaxis and Early Treatment protocol are illustrated in Figures 7. Recent data suggests that ivermectin, melatonin as well as the combination of quercetin (or mixed flavonoids) and vitamin C may play an important role in both pre-exposure and postexposure prophylaxis. [2,9] The evidence supporting the use of Ivermectin for the prophylaxis of COVID-19 is provided by the comprehensive review by Kory et al. [10] It is important to emphasize that ALL of the medications included in our prophylactic regimen are inexpensive, safe, and widely available. The IMASK + protocol MUST be part of an overall strategy which includes common sense public heal