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To: grey_whiskers
" I wasn't aware that viruses in general were known for the quality of their genetic repair; let alone the COOF virus. Do you have a link supporting this characterization, or was it sarcasm?"

Dude, seriously? BTW, that is sarcasm.

C'mon MAN.

"However, coronavirus polymerases, including SARS-CoV-2’s, come uniquely equipped with a sidekick “proofreader protein” that catches most of those errors. It chops out the wrongly inserted chemical component and gives the polymerase another, generally successful, stab at inserting the proper chemical unit into the growing RNA sequence.

The experimental drug remdesivir, approved for emergency use among hospitalized COVID-19 patients, directly targets RNA viruses’ polymerases.

Stanford participated in clinical trials leading to this injectable drug’s approval. Initially developed for treating Ebola virus infection, it belongs to a class of drugs that work by posing as legitimate chemical building blocks of a DNA or RNA sequence. These poseurs get themselves stitched into the nascent strand and gum things up so badly that the polymerase stalls out or produces a defective product."

“Now, with the drug, the virus starts making a lot of rotten genomes that poison the viral replication process,” said Frydman."


"Remdesivir, being a prodrug, is metabolized into its active form GS-441524. As an ATP [Adenosine-5'-triphosphate] analog, GS-441524 competes with ATP for incorporation into RNA and inhibits the action of viral RNA-dependent RNA polymerase.


Remdesivir. is. an. RNA. chain-terminator. spoofing. adenosine [ATP]. in. the. COVID. virus. self-repair. machine. just. like. I. said.

186 posted on 08/01/2021 3:16:56 PM PDT by StAnDeliver (All of you have one of the following in your 401k: Pfizer, Moderna, AstraZeneca, Johnson & Johnson)
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To: StAnDeliver
From earlier in your link:

"A worry: Viral mutation rates are much higher than bacterial rates, which dwarf those of our sperm and egg cells. RNA viruses, including the coronavirus, mutate even more easily than DNA viruses do: Their polymerases (those genome-copying enzymes mentioned earlier) are typically less precise than those of DNA viruses, and RNA itself is inherently less stable than DNA. So viruses, and particularly RNA viruses, easily develop resistance to our immune system’s attempts to find and foil them."

(just *above* the header "The Virus Breaks Into A Cell")

Two sections down, at the bottom, is the passage you quoted.

So your caveat applies specifically to coronaviruses, not to viruses in general; which does in fact answer my question. And from a decently reputable (Stanford) link.

187 posted on 08/01/2021 3:53:00 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: StAnDeliver

Someone pointed out to a certain gassy pro-jabber within the last week that remdesivir was no longer a recommended treatment by the powers that be.


188 posted on 08/01/2021 3:59:47 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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