I have tried to determine exactly:
1. WHY is it more contagious?
2. HOW is it more contagious?
Anyone have any info? I’d appreciate it.
https://www.biorxiv.org/content/10.1101/2021.06.17.448820v1
“Here, we show that the B.1.617 variants are highly fusogenic and form prominent syncytia. Bioinformatic analyses reveal that the P681R mutation in the spike protein is highly conserved in this lineage. Although the P681R mutation decreases viral infectivity, this mutation confers the neutralizing antibody resistance. Notably, we demonstrate that the P681R mutation facilitates the furin-mediated spike cleavage and enhances and accelerates cell-cell fusion.”
LOL! I don’t understand a lick of this either. It’s not just Greek to me, it’s insane!
