University of Minnesota, Mayo report COVID-fighting success with anti-aging therapy
Excerpt:
...Survival increased in mice with COVID-like illnesses when they received drugs that removed senescent cells — sometimes called “retirement” or “zombie” cells that no longer divide or grow, but persist in the body, according to research published Tuesday by Mayo and U researchers in the journal Science.
While success in mice doesn’t guarantee success in people, the results give the researchers confidence as they proceed with two human clinical trials in which they remove senescent cells from COVID-19 patients using high doses of the supplement fisetin.
Team develops potential treatment for life-threatening microbial inflammation
https://medicalxpress.com/news/2021-06-team-potential-treatment-life-threatening-microbial.html
Excerpt:
A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic shock that can result from bacterial and viral infections.
Their findings, published this week in Scientific Reports, could lead to a way to protect patients at highest risk for severe complications and death from out-of-control inflammatory responses to microbial infections, including COVID-19.
“Life-threatening microbial inflammation hits harder (in) patients with metabolic syndrome, a condition afflicting millions of people in the United States and worldwide,” said the paper’s corresponding author, Jacek Hawiger, MD, Ph.D., the Louise B. McGavock Chair in Medicine and Distinguished Professor of Medicine at VUMC.
They used Fisetin.